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Cover A C57BL/6J mouse exploring its own reflection while underlying data highlights a region of copy number variation (turquoise), is representative of new evidence that individual inbred mice, which appear identical, harbor subtle differences in genomic copy number that could significantly influence gene expression and phenotype. (Cover illustration by Darryl Lega. [For details, see Watkins-Chow and Pavan, pp. 60–66.])