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An artist's rendition of the coronavirus responsible for SARS was collapsed to six
gray-scale levels, and each level was mapped to a specific oligonucleotide sequence.
An array containing these oligonucleotide sequences was synthesized on a microscope slide
using a maskless array synthesis process. The array was then hybridized to concentration
gradient of six labeled oligonucleotides. Intensities in the final scanned image correspond
to the concentration of each hybridized oligo. This microarray technology was used to
capture "snap-shots" of the viral genome and track its molecular evolution during the
recent SARS outbreak in Singapore. (Used with permission, Image
Artisan Illustration and Design Ltd.2003, www.artisan.
[For details,see Wong et al.,pp 398-405.])