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Published online before print March 3, 2008, 10.1101/gr.071548.107
Genome Res. 18:544-554, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/08 $5.00
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Letter

No effect of recombination on the efficacy of natural selection in primates

Kevin Bullaughey1,4, Molly Przeworski2,3, and Graham Coop2,3

1 Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA; 2 Department of Human Genetics, University of Chicago, Illinois 60637, USA

Population genetic theory suggests that natural selection should be less effective in regions of low recombination, potentially leading to differences in rates of adaptation among recombination environments. To date, this prediction has mainly been tested in Drosophila, with somewhat conflicting results. We investigated the association between human recombination rates and adaptation in primates, by considering rates of protein evolution (measured by dN/dS) between human, chimpanzee, and rhesus macaque. We found no correlation between either broad- or fine-scale rates of recombination and rates of protein evolution, once GC content is taken into account. Moreover, genes in regions of very low recombination, which are expected to show the most pronounced reduction in the efficacy of selection, do not evolve at a different rate than other genes. Thus, there is no evidence for differences in the efficacy of selection across recombinational environments. An interesting implication is that indirect selection for recombination modifiers has probably been a weak force in primate evolution.

3 These authors co-supervised this work.

4 Corresponding author.

E-mail bullaugh{at}uchicago.edu; fax (773) 834-0505.

[Supplemental material is available online at www.genome.org.]

Article published online before print. Article and publication date are at http://www.genome.org/cgi/doi/10.1101/gr.071548.107.


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