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Letter

mtDNA phylogeny and evolution of laboratory mouse strains

¹ Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), 4200-465 Porto, Portugal; ² Faculdade de Ciências da Universidade do Porto, 4099-002 Porto, Portugal; ³ Medical Faculty, University of Porto, 4200-319 Porto, Portugal; ⁴ The Jackson Laboratory, Bar Harbor, Maine 04609, USA; ⁵ Department of Statistics, University of Glasgow, G12 8QQ Glasgow, United Kingdom

Inbred mouse strains have been maintained for more than 100 years, and they are thought to be a mixture of four different mouse subspecies. Although genealogies have been established, female inbred mouse phylogenies remain unexplored. By a phylogenetic analysis of newly generated complete mitochondrial DNA sequence data in 16 strains, we show here that all common inbred strains descend from the same Mus musculus domesticus female wild ancestor, and suggest that they present a different mitochondrial evolutionary process than their wild relatives with a faster accumulation of replacement substitutions. Our data complement forthcoming results on resequencing of a group of priority strains, and they follow recent efforts of the Mouse Phenome Project to collect and make publicly available information on various strains.

E-mail aalmeida{at}ipatimup.pt; fax +351-22-5570799.

[Supplemental material is available online at www.genome.org. The sequence data from this study have been submitted to GenBank under accession nos. EF108330–EF108345.]

Article published online before print. Article and publication date are online at http://www.genome.org/cgi/doi/10.1101/gr.5941007

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