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Published online before print September 16, 2005
Genome Research, DOI: 10.1101/gr.4086505
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Genome Research Vol 0, Issue 2005, gr.4086505, 2005
© 2005 Cold Spring Harbor Laboratory Press

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Galaxy: A platform for interactive large-scale genome analysis

Belinda Giardine1, Cathy Riemer1, Ross C. Hardison1, Richard Burhans1, Laura Elnitski2, Prachi Shah1,2, Yi Zhang1, Daniel Blankenberg1, Istvan Albert1, Webb Miller1, W. James Kent3 and Anton Nekrutenko1,4

1 Center for Comparative Genomics and Bioinformatics, Huck Institutes for Life Sciences, Penn State University, University Park, Pennsylvania 16802, USA , 2 National Human Genome Research Institute, Bethesda, Maryland 20892, USA , 3 Department of Computer Science and Engineering, University of California at Santa Cruz, Santa Cruz, California 95064, USA

Accessing and analyzing the exponentially expanding genomic sequence and functional data pose a challenge for biomedical researchers. Here we describe an interactive system, Galaxy, that combines the power of existing genome annotation databases with a simple Web portal to enable users to search remote resources, combine data from independent queries, and visualize the results. The heart of Galaxy is a flexible history system that stores the queries from each user; performs operations such as intersections, unions, and subtractions; and links to other computational tools. Galaxy can be accessed at http://g2.bx.psu.edu.

[Supplemental material is available online at www.genome.org.]

Article and publication are at http://www.genome.org/cgi/doi/10.1101/gr.4086505. Article published online before print in September 2005.

4 Corresponding author.
E-mail anton{at}bx.psu.edu; fax (814) 863-6699.


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