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Erratum for Mortimer, Genome Res. 10 (4) 403-409.
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Vol. 10, Issue 6, 891-891, June 2000

ERRATUM

Genome Research 10: 403-409 (2000)

Evolution and Variation of the Yeast (Saccharomyces) Genome

Robert K. Mortimer

On page 406, several denotations of Tables 1 and 2 were incorrect. The corrected version is below:

Genome Renewal as a Mechanism of Evolution of Wine Yeast

Approximately 69% of wine yeast is homothallic and most is diploid (Mortimer et al. 1994; Cavalieri et al. 1998). Many such strains will also sporulate permissively, that is, they will sporulate even on a rich medium. Table 2 describes the heterozygosities seen in 239 strains, of which two-thirds are heterozygous. The traits in wine yeast that are in a heterozygous state cover the spectrum of traits seen in the laboratory studies of this yeast. That natural strains are heterozygous for one or more traits is evidence for mutations occurring during the life of this organism. If an HO/HO strain has heterozygosities and sporulates, the haploid spores from such a strain will represent all possible combinations of these heterozygosities. HO is a gene that causes mating type to switch (Herskowitz 1992). Because of the HO gene, some of the descendants of these haploid spores will change mating type, mate, and form diploids. These diploids will be completely homozygous and will compete with each other and with the original diploid. For n heterozygosities, there will be 2n new individuals. It is our view that the 35% mostly homozygous diploids presented in Table 1 arose by the process of genome renewal from formerly heterozygous diploids.
Most of these homozygous diploids described in Table 1 are in genotypic classes a and b.

10:891-891 ©2000 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/00 $5.00
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D. Cavalieri, J. P. Townsend, and D. L. Hartl
Manifold anomalies in gene expression in a vineyard isolate of Saccharomyces cerevisiae revealed by DNA microarray analysis
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[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Cavalieri, J. P. Townsend, and D. L. Hartl
Manifold anomalies in gene expression in a vineyard isolate of Saccharomyces cerevisiae revealed by DNA microarray analysis
PNAS, October 24, 2000; 97(22): 12369 - 12374.
[Abstract] [Full Text] [PDF]

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