This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Margulies, E. H. PubMed PubMed Citation Articles by Margulies, E. H. Related Content Related Article Social Bookmarking                   What's this?

Commentary

Confidence in comparative genomics

Genome Informatics Section, Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

The first 100 words of the full text of this article appear below.

Comparative sequence analysis has become a widespread approach for identifying and characterizing functional elements encoded within genomic sequences. Marked by early successes (for review, see Hardison 2000), a tremendous amount of sequencing capacity has been, and continues to be, utilized for sequencing genomes of related species. Indeed, the choice of genomes selected for sequencing has less to do with the biology or utility of a particular species as an experimental model organism, but rather is guided more by their placement on the evolutionary tree of life. Optimal species are now characterized by an evolutionary distance (typically measured in neutral . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Related Article

Uncertainty in homology inferences: Assessing and improving genomic sequence alignment

Gerton Lunter, Andrea Rocco, Naila Mimouni, Andreas Heger, Alexandre Caldeira, and Jotun Hein
Genome Res. 2008 18: 298-309. [Abstract] [Full Text] [PDF]