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Commentary

2x genomes—Does depth matter?

Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA

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This issue of Genome Research marks the publication by collaborators at the NIH, Agencourt Bioscience, and the Broad Institute of a genome sequence for the domestic cat Felis catus (Pontius et al. 2007). It was obtained by a whole-genome shotgun approach in which, on average, each genomic base is represented in roughly two sequence reads ("2x" redundancy), a level at which there remain many gaps in the sequence due to statistical fluctuations in read placement, biases in subclone libraries, and assembly difficulties. In all, the NHGRI is sponsoring 24 such "low redundancy" mammalian genome sequences, 17 of . . . [Full Text of this Article]

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Initial sequence and comparative analysis of the cat genome

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