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Genome Res. 17:965-968, 2007
©2007 by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/07 $5.00
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Perspective

Promoting transcriptome diversity

Robert L. Strausberg1 and Samuel Levy

The J. Craig Venter Institute, Rockville, Maryland 20850, USA

Although the number of protein-encoding human genes is more limited than many had estimated, the human transcript repertoire is much more diverse than anticipated. In part, transcript diversity is generated through the use of alternative promoters and alternate splicing. In addition, based on discoveries using technologies such as full-length cDNA libraries and whole genome tiling microarrays, it is now likely that non-protein-encoding transcripts comprise a substantial fraction of the human RNA population. Much attention is currently focused on understanding the role of alternative promoters in generating transcript diversity, both for non-protein-encoding (ncRNAs) and protein-encoding RNAs.

1 Corresponding author.

E-mail rls{at}venterinstitute.org; fax (240) 268-4000.

Article is online at http://www.genome.org/cgi/doi/10.1101/gr.6499807


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