Genome Research songbird

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Erratum (v9,p1156)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhang, M. Q.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, M. Q.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Vol. 9, Issue 8, 681-688, August 1999

PERSPECTIVE
Large-Scale Gene Expression Data Analysis: A New Challenge to Computational Biologists

Michael Q. Zhang

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 USA

The use of high-density DNA arrays to monitor gene expression at a genome-wide scale constitutes a fundamental advance in biology. In particular, the expression pattern of all genes in Saccharomyces cerevisiae can be interrogated using microarray analysis where cDNAs are hybridized to an array of each of the ~6000 genes in the yeast genome. In this survey I review three recent experiments related to transcriptional regulation and discuss the great challenge for computational biologists trying to extract functional information from such large-scale gene expression data.

9:681-688 ©1999 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/99 $5.00
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 BioinformaticsHome page
S. J. Galbraith, L. M. Tran, and J. C. Liao
Transcriptome network component analysis with limited microarray data
Bioinformatics, August 1, 2006; 22(15): 1886 - 1894.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
G. B. Fogel, D. G. Weekes, G. Varga, E. R. Dow, H. B. Harlow, J. E. Onyia, and C. Su
Discovery of sequence motifs related to coexpression of genes using evolutionary computation
Nucleic Acids Res., July 20, 2004; 32(13): 3826 - 3835.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. Xiong, J. Li, and X. Fang
Identification of Genetic Networks
Genetics, February 1, 2004; 166(2): 1037 - 1052.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
P. E. Boardman, S. G. Oliver, and S. J. Hubbard
SiteSeer: visualisation and analysis of transcription factor binding sites in nucleotide sequences
Nucleic Acids Res., July 1, 2003; 31(13): 3572 - 3575.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
D. Farre, R. Roset, M. Huerta, J. E. Adsuara, L. Rosello, M. M. Alba, and X. Messeguer
Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN
Nucleic Acids Res., July 1, 2003; 31(13): 3651 - 3653.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
H. Zhang, Y. Ramanathan, P. Soteropoulos, M. L. Recce, and P. P. Tolias
EZ-Retrieve: a web-server for batch retrieval of coordinate-specified human DNA sequences and underscoring putative transcription factor-binding sites
Nucleic Acids Res., November 1, 2002; 30(21): e121 - e121.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
P.T. Simmons and C. J. Portier
Toxicogenomics: the new frontier in risk analysis
Carcinogenesis, June 1, 2002; 23(6): 903 - 905.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. Zhao, A. Kho, A. M. Kenney, D.-i. Yuk, I. Kohane, and D. H. Rowitch
Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach
PNAS, April 16, 2002; 99(8): 5704 - 5709.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
X. Wang, S. Ghosh, and S.-W. Guo
Quantitative quality control in microarray image processing and data acquisition
Nucleic Acids Res., August 1, 2001; 29(15): e75 - e75.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
R. M. Umek, S. W. Lin, J. Vielmetter, R. H. Terbrueggen, B. Irvine, C. J. Yu, J. F. Kayyem, H. Yowanto, G. F. Blackburn, D. H. Farkas, et al.
Electronic Detection of Nucleic Acids: A Versatile Platform for Molecular Diagnostics
J. Mol. Diagn., May 1, 2001; 3(2): 74 - 84.
[Abstract] [Full Text]

Home page
 Toxicol SciHome page
M. R. Fielden and T. R. Zacharewski
Challenges and Limitations of Gene Expression Profiling in Mechanistic and Predictive Toxicology
Toxicol. Sci., March 1, 2001; 60(1): 6 - 10.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
L. Florea, C. Riemer, S. Schwartz, Z. Zhang, N. Stojanovic, W. Miller, and M. McClelland
Web-based visualization tools for bacterial genome alignments
Nucleic Acids Res., September 15, 2000; 28(18): 3486 - 3496.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
D. Meldrum
Automation for Genomics, Part Two: Sequencers, Microarrays, and Future Trends
Genome Res., September 1, 2000; 10(9): 1288 - 1303.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. J. Bussemaker, H. Li, and E. D. Siggia
Building a dictionary for genomes: Identification of presumptive regulatory sites by statistical analysis
PNAS, August 10, 2000; (2000) 180265397.
[Abstract] [Full Text]

Home page
 Nucleic Acids ResHome page
J. S. Jacobs Anderson and R. Parker
Computational identification of cis-acting elements affecting post-transcriptional control of gene expression in Saccharomyces cerevisiae
Nucleic Acids Res., April 1, 2000; 28(7): 1604 - 1617.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
J. Gécz and J. Mulley
Genes for Cognitive Function: Developments on the X
Genome Res., February 1, 2000; 10(2): 157 - 163.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. J. Bussemaker, H. Li, and E. D. Siggia
From the Cover: Building a dictionary for genomes: Identification of presumptive regulatory sites by statistical analysis
PNAS, August 29, 2000; 97(18): 10096 - 10100.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
K. Birnbaum, P. N. Benfey, and D. E. Shasha
cis Element/Transcription Factor Analysis (cis/TF): A Method for Discovering Transcription Factor/cis Element Relationships
Genome Res., September 1, 2001; 11(9): 1567 - 1573.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genes Dev. Learn. Mem.
Protein Science RNA Genome Res.