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Vol. 9, Issue 6, 581-587, June 1999

LETTER
Physical and Meiotic Mapping of the Region of Human Chromosome 4q11-q13 Encompassing the Vitamin D Binding Protein DBP/Gc-Globulin and Albumin Multigene Cluster

Young-Han Song,1 Anna K. Naumova,1 Stephen A. Liebhaber,1,2 and Nancy E. Cooke1,3

Departments of Medicine, 1 Genetics, and the 2 Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104 USA

The vitamin D binding protein/Gc-globulin (DBP) gene is a member of a multigene cluster that includes albumin (ALB), alpha -fetoprotein (AFP), and alpha -albumin/afamin (AFM). All four genes have structural and functional similarities and map to the same chromosomal regions in humans (4q11-q13), mice, and rats. An accurate physical map of the region encompassing these genes is a prerequisite for study of their respective transcriptional regulation and identification of potential shared regulatory elements. By refining the physical and meiotic maps of the 4q11-q13 region and creating a local PAC contig, the order and transcriptional orientations of these four genes were determined to be centromere-3'-DBP-5'-5'-ALB-3'-5'-AFP-3'-5'-AFM3'-telomere. The ancestral DBP gene was separated from the ALB gene by >1.5 Mb. This organization and spacing establishes a foundation for ongoing functional studies in this region.

3   Corresponding author.

9:581-587 ©1999 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/99 $5.00
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