Genome Research cityscape

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gellner, K.
Right arrow Articles by Brenner, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gellner, K.
Right arrow Articles by Brenner, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Vol. 9, Issue 3, 251-258, March 1999

LETTER
Analysis of 148 kb of Genomic DNA Around the wnt1 Locus of Fugu rubripes

Klaus Gellner,1,2 and Sydney Brenner

Molecular Sciences Institute, Berkeley, California 94704 USA

The analysis of the sequence of ~150 kb of a genomic region corresponding to the wnt1 gene of the Japanese pufferfish Fugu rubripes confirms the compact structure of the genome. Fifteen genes were found in this region, and 26.6% of the analyzed sequence is coding sequence. With an average intergenic distance of <5 kb, this gene density is comparable to that of Caenorhabditis elegans. The compactness of this region corresponds to the reduction of the overall size of the genome, consistent with the conclusion that the gene number in Fugu and human genomes is approximately the same. Eight of the genes have been mapped in the human genome and all of them are found in the chromosomal band 12q13, indicating a high degree of synteny in both species, Fugu and human. Comparative sequence analysis allows us to identify potential regulatory elements for wnt1 and ARF3, which are common to fish and mammals.

[The sequence data described in this paper have been submitted to GenBank under accession no. AF056116.]

1   Present address: Universität Jena, Institut für Spezielle Zoologie und Evolutionsbiologie, 07743 Jena, Germany.
2   Corresponding author.

9:251-258 ©1999 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/99 $5.00
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Genome Res.Home page
T. Dickmeis, C. Plessy, S. Rastegar, P. Aanstad, R. Herwig, F. Chalmel, N. Fischer, and U. Strahle
Expression Profiling and Comparative Genomics Identify a Conserved Regulatory Region Controlling Midline Expression in the Zebrafish Embryo
Genome Res., February 1, 2004; 14(2): 228 - 238.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
U. Pozzoli, G. Elgar, R. Cagliani, L. Riva, G. P. Comi, N. Bresolin, A. Bardoni, and M. Sironi
Comparative Analysis of Vertebrate Dystrophin Loci Indicate Intron Gigantism as a Common Feature
Genome Res., May 1, 2003; 13(5): 764 - 772.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
S. Aparicio, J. Chapman, E. Stupka, N. Putnam, J.-m. Chia, P. Dehal, A. Christoffels, S. Rash, S. Hoon, A. Smit, et al.
Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes
Science, August 23, 2002; 297(5585): 1301 - 1310.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
B. Gottgens, L. M. Barton, M. A. Chapman, A. M. Sinclair, B. Knudsen, D. Grafham, J. G.R. Gilbert, J. Rogers, D. R. Bentley, and A. R. Green
Transcriptional Regulation of the Stem Cell Leukemia Gene (SCL) --- Comparative Analysis of Five Vertebrate SCL Loci
Genome Res., May 1, 2002; 12(5): 749 - 759.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
P. F. Cliften, L. W. Hillier, L. Fulton, T. Graves, T. Miner, W. R. Gish, R. H. Waterston, and M. Johnston
Surveying Saccharomyces Genomes to Identify Functional Elements by Comparative DNA Sequence Analysis
Genome Res., July 1, 2001; 11(7): 1175 - 1186.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. V. Rothenberg
Mapping of complex regulatory elements by pufferfish/zebrafish transgenesis
PNAS, June 5, 2001; 98(12): 6540 - 6542.
[Full Text] [PDF]

Home page
 Genes Dev.Home page
E. V. Pilipenko, T. V. Pestova, V. G. Kolupaeva, E. V. Khitrina, A. N. Poperechnaya, V. I. Agol, and C. U.T. Hellen
A cell cycle-dependent protein serves as a template-specific translation initiation factor
Genes & Dev., August 15, 2000; 14(16): 2028 - 2045.
[Abstract] [Full Text]

Home page
 Genome Res.Home page
H. Davidson, M. S. Taylor, A. Doherty, A. C. Boyd, and D. J. Porteous
Genomic Sequence Analysis of Fugu rubripes CFTR and Flanking Genes in a 60 kb Region Conserving Synteny with 800 kb of Human Chromosome 7
Genome Res., August 1, 2000; 10(8): 1194 - 1203.
[Abstract] [Full Text]

Home page
 Genome Res.Home page
G. Elgar, M. S. Clark, S. Meek, S. Smith, S. Warner, Y. J.K. Edwards, N. Bouchireb, A. Cottage, G. S.H. Yeo, Y. Umrania, et al.
Generation and Analysis of 25 Mb of Genomic DNA from the Pufferfish Fugu rubripes by Sequence Scanning
Genome Res., October 1, 1999; 9(10): 960 - 971.
[Abstract] [Full Text]

Home page
 Hum Mol GenetHome page
J. Gilley and M. Fried
Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes
Hum. Mol. Genet., July 1, 1999; 8(7): 1313 - 1320.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
A. L. Hughes, J. da Silva, and R. Friedman
Ancient Genome Duplications Did Not Structure the Human Hox-Bearing Chromosomes
Genome Res., May 1, 2001; 11(5): 771 - 780.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genes Dev. Learn. Mem.
Protein Science RNA Genome Res.