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Vol. 9, Issue 3, 242-250, March 1999

LETTER
Comparative Genomic Analysis of the Interferon/Interleukin-10 Receptor Gene Cluster

Jérôme Reboul,1 Katheleen Gardiner,2 Danièle Monneron,1 Gilles Uzé,1 and Georges Lutfalla1,3

1 Institut de Génétique Moléculaire, Centre National de la Receherche Scientifique (CNRS)-UMR 5535, 34293 Montpellier CEDEX5, France; 2 Eleanor Roosevelt Institute, Denver, Colorado 80206-1210 USA

Interferons and interleukin-10 are involved in key aspects of the host defence mechanisms. Human chromosome 21 harbors the interferon/interleukin-10 receptor gene cluster linked to the GART gene. This cluster includes both components of the interferon alpha /beta -receptor (IFNAR1 and IFNAR2) and the second components of the interferon gamma -receptor (IFNGR2) and of the IL-10 receptor (IL10R2). We report here the complete gene content of this GART-cytokine receptor gene cluster and the use of comparative genomic analysis to identify chicken IFNAR1, IFNAR2, and IL10R2. We show that the large-scale structure of this locus is conserved in human and chicken but not in the pufferfish Fugu rubripes. This establishes that the receptor components of these host defense mechanisms were fixed in an ancestor of the amniotes. The extraordinary diversification of the interferon ligand family during the evolution of birds and mammals has therefore occured in the context of a fixed receptor structure.

[The sequence data described in this paper have been submitted to GenBank under accession nos. AF039904, AF039905, AF039906, AF039907, AF045606, AF082664, AF082665, AF082666, AF082667, and AF083221.]

3   Corresponding author.

9:242-250 ©1999 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/99 $5.00
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