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Vol. 9, Issue 12, 1223-1230, December 1999

LETTER
Extensive Conservation of Sex Chromosome Organization Between Cat and Human Revealed by Parallel Radiation Hybrid Mapping

William J. Murphy,1,4 Shan Sun,1,2 Zhang-Qun Chen,3 Jill Pecon-Slattery,1 and Stephen J. O'Brien1

1 Laboratory of Genomic Diversity, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201 USA; 2 Graduate Program in Biology, George Mason University, Fairfax, Virginia 22030 USA; 3 Intramural Research Support Program, Science Applications International Corporation Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201 USA

A radiation hybrid (RH)-derived physical map of 25 markers on the feline X chromosome (including 19 Type I coding loci and 6 Type II microsatellite markers) was compared to homologous marker order on the human and mouse X chromosome maps. Complete conservation of synteny and marker order was observed between feline and human X chromosomes, whereas the same markers identified a minimum of seven rearranged syntenic segments between mouse and cat/human X chromosome marker order. Within the blocks, the feline, human, and mouse marker order was strongly conserved. Similarly, Y chromosome locus order was remarkably conserved between cat and human Y chromosomes, with only one marker (SMCY) position rearranged between the species. Tight linkage and a conserved gene order for a segment encoding three genes, DFFRY-DBY-UTY in human, mouse, and cat Y chromosomes, coupled with demonstrated deletion effects of these genes on reproductive impairment in both human and mouse, implicates the region as critical for Y-mediated sperm production.

[The sequence data described in this paper have been submitted to the GenBank data library under accession numbers AF197956-AF197962 and AF197964-AF197972.]

4 Corresponding author.

9:1223-1230 ©1999 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/99 $5.00
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