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Vol. 9, Issue 12, 1214-1222, December 1999

LETTER
Perfect Conserved Linkage Across the Entire Mouse Chromosome 10 Region Homologous to Human Chromosome 21

Tim Wiltshire,1,2,5 Mathew Pletcher,1,5 Susan E. Cole,1,3 Melissa Villanueva,1 Bruce Birren,4 Jessica Lehoczky,4 Ken Dewar,4 and Roger H. Reeves1,6

1 Department of Physiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 USA; 4 Whitehead Institute/MIT Center for Genome Research, Cambridge, Massachusetts 02141 USA

The distal end of human Chromosome (HSA) 21 from PDXK to the telomere shows perfect conserved linkage with mouse Chromosome (MMU) 10. This region is bounded on the proximal side by a segment of homology to HSA22q11.2, and on the distal side by a region of homology with HSA19p13.1. A high-resolution PAC-based physical map is described that spans 2.8 Mb, including the entire 2.1 Mb from Pdxk to Prmt2 corresponding to HSA21. Thirty-four expressed sequences are mapped, three of which were not mapped previously in any species and nine more that are mapped in mouse for the first time. These genes confirm and extend the conserved linkage between MMU10 and HSA21. The ordered PACs and dense STS map provide a clone resource for biological experiments, for rapid and accurate mapping, and for genomic sequencing. The new genes identified here may be involved in Down syndrome (DS) or in several genetic diseases that map to this conserved region of HSA21.

Present addresses: 2Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania 19104 USA; 3Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544 USA.

5 These authors contributed equally to this work.

6 Corresponding author.

9:1214-1222 ©1999 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/99 $5.00
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