Vol. 9, Issue 1, 91-98, January 1999

RESOURCE
"KARIBIN," an Information Resource for Obtaining Genomic Information in a Cytogenetic Band

¹ National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894 USA; ² Glaxo Wellcome, Research Triangle Park, North Carolina 27709-3398 USA; ³ National Cancer Institute, Rockville, Maryland 20892 USA

KARIBIN (http://sgiweb.ncbi.nlm.nih.gov:80/Zjing/yac.html) is a karyotypic region-based integrated information resource that provides a comprehensive view of the integrated mapping and sequencing data for the human genome. A cytogenetic band is linked to a genetic or physical location using fluorescence in situ hybridization (FISH) mapping data. The genetic, physical mapping data and the sequencing data are integrated using STS markers positioned on multiple maps. For each cytogenetic band, the user can obtain the most up-to-date information that includes genetic and physical maps, human transcript gene map, YAC and PAC/BAC clone coverage, disease gene phenotype, and high throughput genomic sequences from the major human genome sequencing centers. This information provides a framework for future experiments and may accelerate the process of disease gene hunting. It is envisioned that other cytogenetic-based information such as chromosome aberrations can be linked to this framework.