Genome Research songbird

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bortoluzzi, S.
Right arrow Articles by Danieli, G. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bortoluzzi, S.
Right arrow Articles by Danieli, G. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

LETTERS
A Comprehensive, High-Resolution Genomic Transcript Map of Human Skeletal Muscle

Stefania Bortoluzzi,1 Luca Rampoldi,1 Barbara Simionati,2 Rosanna Zimbello,2 Alessandro Barbon,1 Fabio d'Alessi,1 Natascia Tiso,1 Alberto Pallavicini,1 Stefano Toppo,2 Nicola Cannata,2 Giorgio Valle,2 Gerolamo Lanfranchi,2 and Gian Antonio Danieli1,3

1 Department of Biology and 2 CRIBI Biotechnology Center, University of Padua, Padua, Italy

We present the Human Muscle Gene Map (HMGM), the first comprehensive and updated high-resolution expression map of human skeletal muscle. The 1078 entries of the map were obtained by merging data retrieved from UniGene with the RH mapping information on 46 novel muscle transcripts, which showed no similarity to any known sequence. In the map, distances are expressed in megabase pairs. About one-quarter of the map entries represents putative novel genes. Genes known to be specifically expressed in muscle account for <4% of the total. The genomic distribution of the map entries confirmed the previous finding that muscle genes are selectively concentrated in chromosomes 17, 19, and X. Five chromosomal regions are suspected to have a significant excess of muscle genes. Present data support the hypothesis that the biochemical and functional properties of differentiated muscle cells may result from the transcription of a very limited number of muscle-specific genes along with the activity of a large number of genes, shared with other tissues, but showing different levels of expression in muscle.

[The sequence data described in this paper have been submitted to the EMBL data library under accession nos. F23198-F23242.]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Genome ResHome page
K. Chase, D. R. Carrier, F. R. Adler, E. A. Ostrander, and K. G. Lark
Interaction between the X chromosome and an autosome regulates size sexual dimorphism in Portuguese Water Dogs
Genome Res., December 1, 2005; 15(12): 1820 - 1824.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. M. Good and M. W. Nachman
Rates of Protein Evolution Are Positively Correlated with Developmental Timing of Expression During Mouse Spermatogenesis
Mol. Biol. Evol., April 1, 2005; 22(4): 1044 - 1052.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
G. A. C. Singer, A. T. Lloyd, L. B. Huminiecki, and K. H. Wolfe
Clusters of Co-expressed Genes in Mammalian Genomes Are Conserved by Natural Selection
Mol. Biol. Evol., March 1, 2005; 22(3): 767 - 775.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
S. T. Kosak and M. Groudine
Form follows function: the genomic organization of cellular differentiation
Genes & Dev., June 15, 2004; 18(12): 1371 - 1384.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Raudsepp, E.-J. Lee, S. R. Kata, C. Brinkmeyer, J. R. Mickelson, L. C. Skow, J. E. Womack, and B. P. Chowdhary
Exceptional conservation of horse-human gene order on X chromosome revealed by high-resolution radiation hybrid mapping
PNAS, February 24, 2004; 101(8): 2386 - 2391.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
M. J. Lercher, T. Blumenthal, and L. D. Hurst
Coexpression of Neighboring Genes in Caenorhabditis Elegans Is Mostly Due to Operons and Duplicate Genes
Genome Res., February 1, 2003; 13(2): 238 - 243.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
M. Steenman, Y.-W. Chen, M. Le Cunff, G. Lamirault, A. Varro, E. Hoffman, and J. J. Leger
Transcriptomal analysis of failing and nonfailing human hearts
Physiol Genomics, January 15, 2003; 12(2): 97 - 112.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. Buraczynska, A. J. Mears, S. Zareparsi, R. Farjo, E. Filippova, Y. Yuan, S. P. MacNee, B. Hughes, and A. Swaroop
Gene Expression Profile of Native Human Retinal Pigment Epithelium
Invest. Ophthalmol. Vis. Sci., March 1, 2002; 43(3): 603 - 607.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. Bortoluzzi, F. d’Alessi, and G. A. Danieli
A Novel Resource for the Study of Genes Expressed in the Adult Human Retina
Invest. Ophthalmol. Vis. Sci., October 1, 2000; 41(11): 3305 - 3308.
[Abstract] [Full Text]

Home page
 Genome ResHome page
M. R. Band, J. H. Larson, M. Rebeiz, C. A. Green, D. W. Heyen, J. Donovan, R. Windish, C. Steining, P. Mahyuddin, J. E. Womack, et al.
An Ordered Comparative Map of the Cattle and Human Genomes
Genome Res., September 1, 2000; 10(9): 1359 - 1368.
[Abstract] [Full Text]

Home page
 Genome ResHome page
S. Bortoluzzi, F. d'Alessi, C. Romualdi, and G. A. Danieli
The Human Adult Skeletal Muscle Transcriptional Profile Reconstructed by a Novel Computational Approach
Genome Res., March 1, 2000; 10(3): 344 - 349.
[Abstract] [Full Text]

Home page
 Genome ResHome page
G. Piétu, E. Eveno, B. Soury-Segurens, N.-A. Fayein, R. Mariage-Samson, C. Matingou, E. Leroy, C. Dechesne, S. Krieger, W. Ansorge, et al.
The Genexpress IMAGE Knowledge Base of the Human Muscle Transcriptome: A Resource of Structural, Functional, and Positional Candidate Genes for Muscle Physiology and Pathologies
Genome Res., December 1, 1999; 9(12): 1313 - 1320.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genes Dev. Learn. Mem.
Protein Science RNA Genome Res.