Genome Research cityscape

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Published online before print December 19, 2005, 10.1101/gr.4624306
Genome Res. 16:164-172, 2006
©2006 by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/06 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Research Data
Right arrow All Versions of this Article:
gr.4624306v1
16/2/164    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Simons, C.
Right arrow Articles by Mattick, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Simons, C.
Right arrow Articles by Mattick, J. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Letter

Transposon-free regions in mammalian genomes

Cas Simons1, Michael Pheasant1, Igor V. Makunin and John S. Mattick2

ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia

Despite the presence of over 3 million transposons separated on average by ~500 bp, the human and mouse genomes each contain almost 1000 transposon-free regions (TFRs) over 10 kb in length. The majority of human TFRs correlate with orthologous TFRs in the mouse, despite the fact that most transposons are lineage specific. Many human TFRs also overlap with orthologous TFRs in the marsupial opossum, indicating that these regions have remained refractory to transposon insertion for long evolutionary periods. Over 90% of the bases covered by TFRs are noncoding, much of which is not highly conserved. Most TFRs are not associated with unusual nucleotide composition, but are significantly associated with genes encoding developmental regulators, suggesting that they represent extended regions of regulatory information that are largely unable to tolerate insertions, a conclusion difficult to reconcile with current conceptions of gene regulation.

Article published online ahead of print. Article and publication date are at http://www.genome.org/cgi/doi/10.1101/gr.4624306.

1 These authors contributed equally to this work.

2 Corresponding author.
E-mail j.mattick{at}imb.uq.edu.au; fax 61-7-3346-2111.

[Supplemental material is available online at www.genome.org.]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
A. Tsirigos and I. Rigoutsos
Human and mouse introns are linked to the same processes and functions through each genome's most frequent non-conserved motifs
Nucleic Acids Res., June 1, 2008; 36(10): 3484 - 3493.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
E. A. Glazov, S. McWilliam, W. C. Barris, and B. P. Dalrymple
Origin, Evolution, and Biological Role of miRNA Cluster in DLK-DIO3 Genomic Region in Placental Mammals
Mol. Biol. Evol., May 1, 2008; 25(5): 939 - 948.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
S. Stephen, M. Pheasant, I. V. Makunin, and J. S. Mattick
Large-Scale Appearance of Ultraconserved Elements in Tetrapod Genomes and Slowdown of the Molecular Clock
Mol. Biol. Evol., February 1, 2008; 25(2): 402 - 408.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
M. Pheasant and J. S. Mattick
Raising the estimate of functional human sequences
Genome Res., September 1, 2007; 17(9): 1245 - 1253.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. B. Lowe, G. Bejerano, and D. Haussler
Thousands of human mobile element fragments undergo strong purifying selection near developmental genes
PNAS, May 8, 2007; 104(19): 8005 - 8010.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
J. S. Mattick
A new paradigm for developmental biology
J. Exp. Biol., May 1, 2007; 210(9): 1526 - 1547.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
H. Kikuta, M. Laplante, P. Navratilova, A. Z. Komisarczuk, P. G. Engstrom, D. Fredman, A. Akalin, M. Caccamo, I. Sealy, K. Howe, et al.
Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates
Genome Res., May 1, 2007; 17(5): 545 - 555.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Albrecht-Buehler
Asymptotically increasing compliance of genomes with Chargaff's second parity rules through inversions and inverted transpositions
PNAS, November 21, 2006; 103(47): 17828 - 17833.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
H. Sun, G. Skogerbo, and R. Chen
Conserved distances between vertebrate highly conserved elements
Hum. Mol. Genet., October 1, 2006; 15(19): 2911 - 2922.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. S. Mattick and I. V. Makunin
Non-coding RNA.
Hum. Mol. Genet., April 15, 2006; 15(suppl_1): R17 - R29.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genes Dev. Learn. Mem.
Protein Science RNA Genome Res.
Copyright © 2006 by Cold Spring Harbor Laboratory Press.