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Regions of high differentiation—Worth a check

Institute for Genetics, Department of Evolutionary Genetics, 50674 Köln, Germany

B. Boursot and K. Belkhir in this issue of Genome Research point to an ascertainment bias in my use of SNPs to identify regions of high differentiation between a pair of house mouse subspecies. Here, I discuss additional points to consider and argue that the ultimate test for such regions should be an independent confirmation using unrelated samples. I provide evidence that regions of high differentiation as identified from laboratory strains and potentially biased SNP markers can be confirmed and therefore are worth a deeper investigation.

[Supplemental material is available online at www.genome.org.]

Article is online at http://www.genome.org/cgi/doi/10.1101/gr.5787706.

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