This Article Full Text Full Text (PDF) Supplemental Research Data Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yogeeswaran, K. Articles by Nasrallah, M. E. Search for Related Content PubMed PubMed Citation Articles by Yogeeswaran, K. Articles by Nasrallah, M. E. Social Bookmarking                   What's this?

Letter

Comparative genome analyses of Arabidopsis spp.: Inferring chromosomal rearrangement events in the evolutionary history of A. thaliana

¹ Department of Plant Biology, Cornell University, Ithaca, New York 14853, USA ² Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York 14853, USA ³ Department of Plant Breeding, Cornell University, Ithaca, New York 14853, USA ⁴ Department of Biological Sciences, Mount Holyoke College, South Hadley, Massachusetts 01075, USA

Comparative genome analysis is a powerful tool that can facilitate the reconstruction of the evolutionary history of the genomes of modern-day species. The model plant Arabidopsis thaliana with its n = 5 genome is thought to be derived from an ancestral n = 8 genome. Pairwise comparative genome analyses of A. thaliana with polyploid and diploid Brassicaceae species have suggested that rapid genome evolution, manifested by chromosomal rearrangements and duplications, characterizes the polyploid, but not the diploid, lineages of this family. In this study, we constructed a low-density genetic linkage map of Arabidopsis lyrata ssp. lyrata (A. l. lyrata; n = 8, diploid), the closest known relative of A. thaliana (MRCA 5 Mya), using A. thaliana-specific markers that resolve into the expected eight linkage groups. We then performed comparative Bayesian analyses using raw mapping data from this study and from a Capsella study to infer the number and nature of rearrangements that distinguish the n = 8 genomes of A. l. lyrata and Capsella from the n = 5 genome of A. thaliana. We conclude that there is strong statistical support in favor of the parsimony scenarios of 10 major chromosomal rearrangements separating these n = 8 genomes from A. thaliana. These chromosomal rearrangement events contribute to a rate of chromosomal evolution higher than previously reported in this lineage. We infer that at least seven of these events, common to both sets of data, are responsible for the change in karyotype and underlie genome reduction in A. thaliana.

⁵ Present address: Dept. of Neuroscience, Brown Univ., Providence, RI 02912, USA

⁶ Present address: Dept. of Natural Resources, Cornell Univ., Ithaca, NY 14853, USA.

⁷ Corresponding author.
E-mail men4{at}cornell.edu; fax (607) 255-5407.

[Supplemental material is available online at www.genome.org. The following individuals kindly provided reagents, samples, or unpublished information as indicated in the paper: C. Langley.]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				H. Tang, J. E. Bowers, X. Wang, R. Ming, M. Alam, and A. H. Paterson Synteny and Collinearity in Plant Genomes Science, April 25, 2008; 320(5875): 486 - 488. [Abstract] [Full Text] [PDF]

				T. Slotte, K. Holm, L. M. McIntyre, U. Lagercrantz, and M. Lascoux Differential Expression of Genes Important for Adaptation in Capsella bursa-pastoris (Brassicaceae) Plant Physiology, September 1, 2007; 145(1): 160 - 173. [Abstract] [Full Text] [PDF]

				H. Kim, P. S. Miguel, W. Nelson, K. Collura, M. Wissotski, J. G. Walling, J. P. Kim, S. A. Jackson, C. Soderlund, and R. A. Wing Comparative Physical Mapping Between Oryza sativa (AA Genome Type) and O. punctata (BB Genome Type) Genetics, May 1, 2007; 176(1): 379 - 390. [Abstract] [Full Text] [PDF]

				G. Willems, D. B. Drager, M. Courbot, C. Gode, N. Verbruggen, and P. Saumitou-Laprade The Genetic Basis of Zinc Tolerance in the Metallophyte Arabidopsis halleri ssp. halleri (Brassicaceae): An Analysis of Quantitative Trait Loci Genetics, May 1, 2007; 176(1): 659 - 674. [Abstract] [Full Text] [PDF]

				M. E. Schranz, A. J. Windsor, B.-h. Song, A. Lawton-Rauh, and T. Mitchell-Olds Comparative Genetic Mapping in Boechera stricta, a Close Relative of Arabidopsis Plant Physiology, May 1, 2007; 144(1): 286 - 298. [Abstract] [Full Text] [PDF]

				M. A. Koch and M. Matschinger Evolution and genetic differentiation among relatives of Arabidopsis thaliana PNAS, April 10, 2007; 104(15): 6272 - 6277. [Abstract] [Full Text] [PDF]

				J. B. Nasrallah, P. Liu, S. Sherman-Broyles, R. Schmidt, and M. E. Nasrallah Epigenetic Mechanisms for Breakdown of Self-Incompatibility in Interspecific Hybrids Genetics, April 1, 2007; 175(4): 1965 - 1973. [Abstract] [Full Text] [PDF]

				J. Gonzalez, F. Casals, and A. Ruiz Testing Chromosomal Phylogenies and Inversion Breakpoint Reuse in Drosophila Genetics, January 1, 2007; 175(1): 167 - 177. [Abstract] [Full Text] [PDF]

				A. Kawabe, S. Nasuda, and D. Charlesworth Duplication of Centromeric Histone H3 (HTR12) Gene in Arabidopsis halleri and A. lyrata, Plant Species With Multiple Centromeric Satellite Sequences Genetics, December 1, 2006; 174(4): 2021 - 2032. [Abstract] [Full Text] [PDF]

				I. N. Talke, M. Hanikenne, and U. Kramer Zinc-Dependent Global Transcriptional Control, Transcriptional Deregulation, and Higher Gene Copy Number for Genes in Metal Homeostasis of the Hyperaccumulator Arabidopsis halleri Plant Physiology, September 1, 2006; 142(1): 148 - 167. [Abstract] [Full Text] [PDF]

				A. Kawabe, B. Hansson, J. Hagenblad, A. Forrest, and D. Charlesworth Centromere Locations and Associated Chromosome Rearrangements in Arabidopsis lyrata and A. thaliana Genetics, July 1, 2006; 173(3): 1613 - 1619. [Abstract] [Full Text] [PDF]

				R. Koszul, B. Dujon, and G. Fischer Stability of Large Segmental Duplications in the Yeast Genome Genetics, April 1, 2006; 172(4): 2211 - 2222. [Abstract] [Full Text] [PDF]

				A. J. Windsor, M. E. Schranz, N. Formanova, S. Gebauer-Jung, J. G. Bishop, D. Schnabelrauch, J. Kroymann, and T. Mitchell-Olds Partial Shotgun Sequencing of the Boechera stricta Genome Reveals Extensive Microsynteny and Promoter Conservation with Arabidopsis. Plant Physiology, April 1, 2006; 140(4): 1169 - 1182. [Abstract] [Full Text] [PDF]

				M. A. Lysak, A. Berr, A. Pecinka, R. Schmidt, K. McBreen, and I. Schubert Mechanisms of chromosome number reduction in Arabidopsis thaliana and related Brassicaceae species PNAS, March 28, 2006; 103(13): 5224 - 5229. [Abstract] [Full Text] [PDF]

				A. E. Hall, G. C. Kettler, and D. Preuss Dynamic evolution at pericentromeres Genome Res., March 1, 2006; 16(3): 355 - 364. [Abstract] [Full Text] [PDF]