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Genome Res. 15:1611-1619, 2005
©2005 by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/05 $5.00
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Perspective

Changing perspectives in yeast research nearly a decade after the genome sequence

Kara Dolinski and David Botstein1

Lewis-Sigler Institute for Integrative Genomics, Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544 USA

Research with budding yeast (Saccharomyces cerevisiae) has been transformed by the publication, nearly a decade ago, of the entire genome DNA sequence. The introduction of this first eukaryotic genomic sequence changed the yeast research environment significantly, not just because of dramatic progress in technical means but also because the sequence made accessible a new class of scientific questions. A central goal of yeast research remains the determination of the biological role of every sequence feature in the yeast genome. The most remarkable change has been the shift in perspective from focus on individual genes and functionalities to a more global view of how the cellular networks and systems interact and function together to produce the highly evolved organism we see today.

Article and publication are at http://www.genome.org/cgi/doi/10.1101/gr.3727505.

1 Corresponding author.
E-mail botstein{at}princeton.edu; fax (609) 258-7070.


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