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Published online before print September 16, 2005, 10.1101/gr.4086505
Genome Res. 15:1451-1455, 2005
©2005 by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/05 $5.00
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Galaxy: A platform for interactive large-scale genome analysis

Belinda Giardine1, Cathy Riemer1, Ross C. Hardison1, Richard Burhans1, Laura Elnitski2, Prachi Shah1,2, Yi Zhang1, Daniel Blankenberg1, Istvan Albert1, James Taylor1, Webb Miller1, W. James Kent3 and Anton Nekrutenko1,4

1 Center for Comparative Genomics and Bioinformatics, Huck Institutes for Life Sciences, Penn State University, University Park, Pennsylvania 16802, USA 2 National Human Genome Research Institute, Bethesda, Maryland 20892, USA 3 Department of Computer Science and Engineering, University of California at Santa Cruz, Santa Cruz, California 95064, USA

Accessing and analyzing the exponentially expanding genomic sequence and functional data pose a challenge for biomedical researchers. Here we describe an interactive system, Galaxy, that combines the power of existing genome annotation databases with a simple Web portal to enable users to search remote resources, combine data from independent queries, and visualize the results. The heart of Galaxy is a flexible history system that stores the queries from each user; performs operations such as intersections, unions, and subtractions; and links to other computational tools. Galaxy can be accessed at http://g2.bx.psu.edu.

Article and publication are at http://www.genome.org/cgi/doi/10.1101/gr.4086505. Article published online before print in September 2005.

4 Corresponding author.
E-mail anton{at}bx.psu.edu; fax (814) 863-6699.

[Supplemental material is available online at www.genome.org.]


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