Genome Research scroll

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Published online before print September 13, 2004, 10.1101/gr.2478604
Genome Res. 14:1888-1901, 2004
©2004 by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
gr.2478604v1
14/10a/1888    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mallon, A.-M.
Right arrow Articles by Brown, S. D.M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mallon, A.-M.
Right arrow Articles by Brown, S. D.M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Letter

Organization and Evolution of a Gene-Rich Region of the Mouse Genome: A 12.7-Mb Region Deleted in the Del(13)Svea36H Mouse

Ann-Marie Mallon1,4, Laurens Wilming2,4, Joseph Weekes1, James G.R. Gilbert2, Jennifer Ashurst2, Sandrine Peyrefitte2, Lucy Matthews2, Matthew Cadman1, Richard McKeone1, Chris A. Sellick1, Ruth Arkell1, Marc R.M. Botcherby3, Mark A. Strivens1, R. Duncan Campbell3, Simon Gregory2,5, Paul Denny1, John M. Hancock1,6, Jane Rogers2 and Steve D.M. Brown1

1 Medical Research Council Mammalian Genetics Unit, Harwell, Oxfordshire, United Kingdom 2 Wellcome Trust Sanger Institute, Hinxton Genome Campus, United Kingdom 3 Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton Genome Campus, United Kingdom

Del(13)Svea36H (Del36H) is a deletion of ~20% of mouse chromosome 13 showing conserved synteny with human chromosome 6p22.1-6p22.3/6p25. The human region is lost in some deletion syndromes and is the site of several disease loci. Heterozygous Del36H mice show numerous phenotypes and may model aspects of human genetic disease. We describe 12.7 Mb of finished, annotated sequence from Del36H. Del36H has a higher gene density than the draft mouse genome, reflecting high local densities of three gene families (vomeronasal receptors, serpins, and prolactins) which are greatly expanded relative to human. Transposable elements are concentrated near these gene families. We therefore suggest that their neighborhoods are gene factories, regions of frequent recombination in which gene duplication is more frequent. The gene families show different proportions of pseudogenes, likely reflecting different strengths of purifying selection and/or gene conversion. They are also associated with relatively low simple sequence concentrations, which vary across the region with a periodicity of ~5 Mb. Del36H contains numerous evolutionarily conserved regions (ECRs). Many lie in noncoding regions, are detectable in species as distant as Ciona intestinalis, and therefore are candidate regulatory sequences. This analysis will facilitate functional genomic analysis of Del36H and provides insights into mouse genome evolution.

4 These two authors contributed equally to this work.

5 Present address: Center for Human Genetics, Duke University Medical Center, Durham, 27710 NC, USA.

6 Corresponding author.
E-MAIL j.hancock{at}har.mrc.ac.uk; FAX 44-1235-834-776.

Article and publication are at http://www.genome.org/cgi/doi/10.1101/gr.2478604. Article published online before print in September 2004.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Caputi, N. Andreakis, F. Mastrototaro, P. Cirino, M. Vassillo, and P. Sordino
Cryptic speciation in a model invertebrate chordate
PNAS, May 29, 2007; 104(22): 9364 - 9369.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. K. Ho-Chen, J. J. Bustamante, and M. J. Soares
Prolactin-Like Protein-F Subfamily of Placental Hormones/Cytokines: Responsiveness to Maternal Hypoxia
Endocrinology, February 1, 2007; 148(2): 559 - 565.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
V. Katju and M. Lynch
On the Formation of Novel Genes by Duplication in the Caenorhabditis elegans Genome
Mol. Biol. Evol., May 1, 2006; 23(5): 1056 - 1067.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. M. Smyth, L. Wilming, A. W. Lee, M. S. Taylor, P. Gautier, K. Barlow, J. Wallis, S. Martin, R. Glithero, B. Phillimore, et al.
Genomic anatomy of the Tyrp1 (brown) deletion complex
PNAS, March 7, 2006; 103(10): 3704 - 3709.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Bogani, C. Willoughby, J. Davies, K. Kaur, G. Mirza, A. Paudyal, H. Haines, R. McKeone, M. Cadman, G. Pieles, et al.
Dissecting the genetic complexity of human 6p deletion syndromes by using a region-specific, phenotype-driven mouse screen
PNAS, August 30, 2005; 102(35): 12477 - 12482.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. L. Ashurst, C.-K. Chen, J. G. R. Gilbert, K. Jekosch, S. Keenan, P. Meidl, S. M. Searle, J. Stalker, R. Storey, S. Trevanion, et al.
The Vertebrate Genome Annotation (Vega) database
Nucleic Acids Res., January 1, 2005; 33(suppl_1): D459 - D465.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genes Dev. Learn. Mem.
Protein Science RNA Genome Res.
Copyright © 2004 by Cold Spring Harbor Laboratory Press.