This Article Full Text Full Text (PDF) Supplemental Research Data Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Huminiecki, L. Articles by Wolfe, K. H. Search for Related Content PubMed PubMed Citation Articles by Huminiecki, L. Articles by Wolfe, K. H. Social Bookmarking                   What's this?

Letter

Divergence of Spatial Gene Expression Profiles Following Species-Specific Gene Duplications in Human and Mouse

Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, Dublin 2, Ireland

To examine the process by which duplicated genes diverge in function, we studied how the gene expression profiles of orthologous gene sets in human and mouse are affected by the presence of additional recent species-specific paralogs. Gene expression profiles were compared across 16 homologous tissues in human and mouse using microarray data from the Gene Expression Atlas for 1575 sets of orthologs including 250 with species-specific paralogs. We find that orthologs that have undergone recent duplication are less likely to have strongly correlated expression profiles than those that remain in a one-to-one relationship between human and mouse. There is a general trend for paralogous genes to become more specialized in their expression patterns, with decreased breadth and increased specificity of expression as gene family size increases. Despite this trend, detailed examination of some particular gene families where species-specific duplications have occurred indicated several examples of apparent neofunctionalization of duplicated genes, but only one case of subfunctionalization. Often, the expression of both copies of a duplicated gene appears to have changed relative to the ancestral state. Our results suggest that gene expression profiles are surprisingly labile and that expression in a particular tissue may be gained or lost repeatedly during the evolution of even small gene families. We conclude that gene duplication is a major driving force behind the emergence of divergent gene expression patterns.

² Corresponding author.
E-MAIL Lukasz.Huminiecki{at}cgb.ki.se; FAX +46-8-323950.

[Supplemental material is available online at www.genome.org.]

Article and publication are at http://www.genome.org/cgi/doi/10.1101/gr.2705204.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				X. Gu and Z. Su Tissue-driven hypothesis of genomic evolution and sequence-expression correlations PNAS, February 20, 2007; 104(8): 2779 - 2784. [Abstract] [Full Text] [PDF]

				K. Zhan, Z. C. Hou, H. F. Li, G. Y. Xu, R. Zhao, and N. Yang Molecular Cloning and Expression of the Duplicated Thyroid Hormone Responsive Spot 14 (THRSP) Genes in Ducks. Poult. Sci., October 1, 2006; 85(10): 1746 - 1754. [Abstract] [Full Text] [PDF]

				B.-Y. Liao and J. Zhang Low Rates of Expression Profile Divergence in Highly Expressed Genes and Tissue-Specific Genes During Mammalian Evolution Mol. Biol. Evol., June 1, 2006; 23(6): 1119 - 1128. [Abstract] [Full Text] [PDF]

				S. De Bodt, G. Theissen, and Y. Van de Peer Promoter Analysis of MADS-Box Genes in Eudicots Through Phylogenetic Footprinting Mol. Biol. Evol., June 1, 2006; 23(6): 1293 - 1303. [Abstract] [Full Text] [PDF]

				B.-Y. Liao and J. Zhang Evolutionary Conservation of Expression Profiles Between Human and Mouse Orthologous Genes Mol. Biol. Evol., March 1, 2006; 23(3): 530 - 540. [Abstract] [Full Text] [PDF]

				O. Ogasawara, M. Otsuji, K. Watanabe, T. Iizuka, T. Tamura, T. Hishiki, S. Kawamoto, and K. Okubo BodyMap-Xs: anatomical breakdown of 17 million animal ESTs for cross-species comparison of gene expression Nucleic Acids Res., January 1, 2006; 34(suppl_1): D628 - D631. [Abstract] [Full Text] [PDF]

				B. P. Cusack and K. H. Wolfe Changes in Alternative Splicing of Human and Mouse Genes Are Accompanied by Faster Evolution of Constitutive Exons Mol. Biol. Evol., November 1, 2005; 22(11): 2198 - 2208. [Abstract] [Full Text] [PDF]

				W. Gu, Y. Gibert, T. Wirth, A. Elischer, W. Bloch, A. Meyer, O. K. Steinlein, and G. Begemann Using Gene-History and Expression Analyses to Assess the Involvement of LGI Genes in Human Disorders Mol. Biol. Evol., November 1, 2005; 22(11): 2209 - 2216. [Abstract] [Full Text] [PDF]

				J. Yang, A. I. Su, and W.-H. Li Gene Expression Evolves Faster in Narrowly Than in Broadly Expressed Mammalian Genes Mol. Biol. Evol., October 1, 2005; 22(10): 2113 - 2118. [Abstract] [Full Text] [PDF]

				R. A. Veitia Paralogs in Polyploids: One for All and All for One? PLANT CELL, January 1, 2005; 17(1): 4 - 11. [Full Text] [PDF]