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Methods

Human Disease Genes and Their Cloned Mouse Orthologs: Exploration of the FANTOM2 cDNA Sequence Data Set

¹National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland 20894, USA ²The Jackson Laboratory, Bar Harbor, Maine 04609, USA ³Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan ⁴Departments of Pediatrics and Medicine, University of California, San Diego School of Medicine, San Diego, California 92093, USA ⁵National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-4472, USA ⁶Applied Genomics, Inc., Sunnyvale, California 94085, USA ⁷Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA ⁸Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan ⁹Genome Science Laboratory, RIKEN, Hirosawa, Wako, Saitama 351-0198, Japan

The FANTOM2 cDNA sequence data set is an excellent model to demonstrate the power of large-scale cDNA sequencing, with the goal of providing a full-length transcript sequence for each mouse gene. This data set enhances the use of the mouse as a model for human disease. Here we identify mouse cDNA sequences in the FANTOM2 data set for a set of 67 human disease genes that as of May 2002 had no corresponding mouse cDNA annotated in the Mouse Genome Informatics (MGI) database. These 67 human disease genes include genes related to neurological and eye disorders and cancer. We also present a list of the human disease genes and their cloned mouse orthologs found in two public databases, LocusLink and MGI. Allelic variant and gene functional information available in MGI provides additional information relative to these mouse models, whereas computed sequence-based connections at NCBI support facile navigation through multiple genomes.

¹¹ Corresponding author.
E-MAIL schriml{at}ncbi.nlm.nih.gov; FAX (301) 480-2288.

¹⁰ Yoshihide Hayashizaki, Takahiro Arakawa, Piero Carninci, and Jun Kawai.

[Supplemental material is available online at www.genome.org.]

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