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Letter

Analysis of the Mouse Transcriptome for Genes Involved in the Function of the Nervous System

¹Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA ²Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, USA ³Boys Town National Research Hospital, Omaha, Nebraska 68131, USA ⁴Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan ⁵Genome Science Laboratory, RIKEN, Hireosawa, Wako, Saitama, 351-0198, Japan ⁶The Scripps Research Institute, La Jolla, California 92037, USA ⁷Institute for Molecule Bioscience and ARC Special Research Centre for Functional and Applied Genomics, University of Queensland, Q4072, Australia ⁸Graduate School of Medicine, University of Tokyo, Tokyo, 113-0033, Japan ⁹Duke University Medical Center, Department of Neurobiology, Durham, North Carolina 27710, USA ¹⁰Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA ¹¹Department of Psychiatry, University of Bonn, Bonn 53105, Germany

We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function.We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins.We also identified previously unknown candidates for secreted neuroactive molecules.The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored.A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.

¹³ Present address: Laboratory of Molecular Neurobiology, International School for Advanced Studies S.I.S.S.A., Area Science Park, Trieste, Italy.

¹⁴ Corresponding author.
E-MAIL gustinci{at}sissa.it; FAX 39 (040) 375-6502.

¹² Takahiro Arakawa,⁴ Kazunori Waki,⁴ and Jun Kawai^4,5

[Supplemental material is available online at www.genome.org.]

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