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Published online before print May 12, 2003, 10.1101/gr.946403
Genome Res. 13:1029-1041, 2003
©2003 by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/03 $5.00
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Perspective

Genome Function and Nuclear Architecture: From Gene Expression to Nanoscience

Timothy P. O'Brien1,9, Carol J. Bult1, Christoph Cremer2, Michael Grunze2, Barbara B. Knowles1, Jörg Langowski3, James McNally4, Thoru Pederson5, Joan C. Politz5, Ana Pombo6, Günter Schmahl7, Joachim P. Spatz2 and Roel van Driel8

1 The Jackson Laboratory, Bar Harbor, Maine 04609, USA 2 University of Heidelberg, D-69117 Heidelberg, Germany 3 German Cancer Research Center, 69120 Heidelberg, Germany 4 National Cancer Institute, Bethesda, Maryland 20892, USA 5 University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA 6 MRC Clinical Sciences Centre, London W12 ONN, UK 7 University of Goettingen, 37070 Goettingen, Germany 8 University of Amsterdam, 1018 TV Amsterdam, The Netherlands

Biophysical, chemical, and nanoscience approaches to the study of nuclear structure and activity have been developing recently and hold considerable promise. A selection of fundamental problems in genome organization and function are reviewed and discussed in the context of these new perspectives and approaches. Advancing these concepts will require coordinated networks of physicists, chemists, and materials scientists collaborating with cell, developmental, and genome biologists.

Article and publication are at http://www.genome.org/cgi/doi/10.1101/gr.946403. Article published online before print in May 2003.

9 Corresponding author.
E-MAIL tpo{at}jax.org; FAX (207) 288-6073.


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