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Vol. 12, Issue 8, 1185-1189, August 2002

LETTER
Minimal Introns Are Not "Junk"

Jun Yu,1,2,3,5,6 Zhiyong Yang,4,5 Miho Kibukawa,1 Marcia Paddock,1 Douglas A. Passey,1 and Gane Ka-Shu Wong1,2,3

1 University of Washington Genome Center, Department of Medicine, Seattle, Washington 98195, USA; 2 Hangzhou Genomics Institute, Institute of Bioinformatics of Zhejiang University, Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China; 3 Beijing Genomics Institute, Center of Genomics and Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China; 4 Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia.

Intron-size distributions for most multicellular (and some unicellular) eukaryotes have a sharp peak at their "minimal intron" size. Across the human population, these minimal introns exhibit an abundance of insertion-deletion polymorphisms, the effect of which is to maintain their optimal size. We argue that minimal introns affect function by enhancing the rate at which mRNA is exported from the cell nucleus.

5 These authors contributed equally to this work.

6 Corresponding author.

12:1185-1189 ©2002 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/02 $5.00
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