Genome Research scroll

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Published online before print May 16, 2002, 10.1101/gr.227202. Article published online before print in May 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Research Data
Right arrow All Versions of this Article:
GR-2272Rv1
12/6/885    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Woischnik, M.
Right arrow Articles by Moraes, C. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Woischnik, M.
Right arrow Articles by Moraes, C. T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Vol. 12, Issue 6, 885-893, June 2002

Pattern of Organization of Human Mitochondrial Pseudogenes in the Nuclear Genome

Markus Woischnik, and Carlos T. Moraes1

Department of Neurology, University of Miami-School of Medicine, Miami, Florida 33136, USA

Mitochondrial pseudogenes in the human nuclear genome have been previously described, mostly as a source of artifacts during the analysis of the mitochondrial genome. With the availability of the complete human genome sequence, we performed a comprehensive analysis of mtDNA insertions into the nucleus. We found 612 independent integrations that are evenly distributed among all chromosomes as well as within each individual chromosome. The identified pseudogenes account for a content of at least 0.016% of the human nuclear DNA. Up to 30% of a chromosome's mtDNA pseudogene content is composed of fragments that encompass two or more adjacent mitochondrial genes, and we found no correlation between the abundance of mitochondrial transcripts and the multiplicity of integrations. These observations indicate that the migrations of mitochondrial DNA sequences to the nucleus were predominantly DNA mediated. Phylogenetic analysis of the mtDNA pseudogenes and mtDNA sequences of primates indicate a continuous transfer into the nucleus. Because of the limited window of opportunity for mtDNA transfer to the germline, sperm mtDNA, which is released from degenerating mitochondria after fertilization, could be an important source of nuclear mtDNA pseudogenes.

[Online supplemental material available at http://www.genome.org]

1 Corresponding author.

12:885-893 ©2002 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/02 $5.00
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Genome Res.Home page
N. Nikoh, K. Tanaka, F. Shibata, N. Kondo, M. Hizume, M. Shimada, and T. Fukatsu
Wolbachia genome integrated in an insect chromosome: Evolution and fate of laterally transferred endosymbiont genes
Genome Res., February 1, 2008; 18(2): 272 - 280.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. Villegas, V. Burzio, C. Villota, E. Landerer, R. Martinez, M. Santander, R. Martinez, R. Pinto, M. I. Vera, E. Boccardo, et al.
Expression of a novel non-coding mitochondrial RNA in human proliferating cells
Nucleic Acids Res., December 18, 2007; 35(21): 7336 - 7347.
[Abstract] [Full Text] [PDF]

Home page
 J HeredHome page
A. Antunes, J. Pontius, M. J. Ramos, S. J. O'Brien, and W. E. Johnson
Mitochondrial Introgressions into the Nuclear Genome of the Domestic Cat
J. Hered., July 28, 2007; (2007) esm062v1.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
S. K. Behura
Analysis of Nuclear Copies of Mitochondrial Sequences in Honeybee (Apis mellifera) Genome
Mol. Biol. Evol., July 1, 2007; 24(7): 1492 - 1505.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
P. Pamilo, L. Viljakainen, and A. Vihavainen
Exceptionally High Density of NUMTs in the Honeybee Genome
Mol. Biol. Evol., June 1, 2007; 24(6): 1340 - 1346.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. Srivastava, J. N. Barrett, and C. T. Moraes
PGC-1{alpha}/{beta} upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations
Hum. Mol. Genet., April 15, 2007; 16(8): 993 - 1005.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
E. Hazkani-Covo and D. Graur
A Comparative Analysis of numt Evolution in Human and Chimpanzee
Mol. Biol. Evol., January 1, 2007; 24(1): 13 - 18.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. Qu, R. Li, X. Zhou, Y. Tong, F. Lu, Y. Qian, Y. Hu, J. Q. Mo, C. E. West, and M.-X. Guan
The Novel A4435G Mutation in the Mitochondrial tRNAMet May Modulate the Phenotypic Expression of the LHON-Associated ND4 G11778A Mutation
Invest. Ophthalmol. Vis. Sci., February 1, 2006; 47(2): 475 - 483.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Decottignies
Capture of Extranuclear DNA at Fission Yeast Double-Strand Breaks
Genetics, December 1, 2005; 171(4): 1535 - 1548.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Slomovic, D. Laufer, D. Geiger, and G. Schuster
Polyadenylation and Degradation of Human Mitochondrial RNA: the Prokaryotic Past Leaves Its Mark
Mol. Cell. Biol., August 1, 2005; 25(15): 6427 - 6435.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
C. Noutsos, E. Richly, and D. Leister
Generation and evolutionary fate of insertions of organelle DNA in the nuclear genomes of flowering plants
Genome Res., May 1, 2005; 15(5): 616 - 628.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. Pons and A. P. Vogler
Complex Pattern of Coalescence and Fast Evolution of a Mitochondrial rRNA Pseudogene in a Recent Radiation of Tiger Beetles
Mol. Biol. Evol., April 1, 2005; 22(4): 991 - 1000.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
M. Matsuo, Y. Ito, R. Yamauchi, and J. Obokata
The Rice Nuclear Genome Continuously Integrates, Shuffles, and Eliminates the Chloroplast Genome to Cause Chloroplast-Nuclear DNA Flux
PLANT CELL, March 1, 2005; 17(3): 665 - 675.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
E. Richly and D. Leister
NUPTs in Sequenced Eukaryotes and Their Genomic Organization in Relation to NUMTs
Mol. Biol. Evol., October 1, 2004; 21(10): 1972 - 1980.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
E. Richly and D. Leister
NUMTs in Sequenced Eukaryotic Genomes
Mol. Biol. Evol., June 1, 2004; 21(6): 1081 - 1084.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
Z. Zhang, P. M. Harrison, Y. Liu, and M. Gerstein
Millions of Years of Evolution Preserved: A Comprehensive Catalog of the Processed Pseudogenes in the Human Genome
Genome Res., December 1, 2003; 13(12): 2541 - 2558.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Oca-Cossio, L. Kenyon, H. Hao, and C. T. Moraes
Limitations of Allotopic Expression of Mitochondrial Genes in Mammalian Cells
Genetics, October 1, 2003; 165(2): 707 - 720.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. W.K. Chiu, L. Y.S. Chan, N. Y.L. Lam, N. B.Y. Tsui, E. K.O. Ng, T. H. Rainer, and Y.M. D. Lo
Quantitative Analysis of Circulating Mitochondrial DNA in Plasma
Clin. Chem., May 1, 2003; 49(5): 719 - 726.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
P. May-Panloup, M-F. Chretien, F. Savagner, C. Vasseur, M. Jean, Y. Malthiery, and P. Reynier
Increased sperm mitochondrial DNA content in male infertility
Hum. Reprod., March 1, 2003; 18(3): 550 - 556.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genes Dev. Learn. Mem.
Protein Science RNA Genome Res.