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Vol. 12, Issue 6, 857-867, June 2002
Fourfold Faster Rate of Genome Rearrangement in Nematodes Than in Drosophila
Avril
Coghlan, and
Kenneth H.
Wolfe1
Department of Genetics, Smurfit Institute, University of Dublin,
Trinity College, Dublin 2, Ireland
We compared the genome of the nematode Caenorhabditis
elegans to 13% of that of Caenorhabditis briggsae,
identifying 252 conserved segments along their chromosomes. We detected
517 chromosomal rearrangements, with the ratio of translocations to
inversions to transpositions being ~1:1:2. We estimate that
the species diverged 50-120 million years ago, and that since then
there have been 4030 rearrangements between their whole genomes. Our
estimate of the rearrangement rate, 0.4-1.0 chromosomal breakages/Mb
per Myr, is at least four times that of Drosophila, which was
previously reported to be the fastest rate among eukaryotes. The
breakpoints of translocations are strongly associated with dispersed
repeats and gene family members in the C. elegans genome.
[The following institution kindly provided
reagents, samples or unpublished information as indicated in the paper:
Genome Sequencing Center, Washington University School of Medicine, St. Louis.]
1
Corresponding author.
12:857-867 ©2002 by Cold Spring Harbor Laboratory Press ISSN 1088-9051/02 $5.00
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