Genome Research scroll

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Published online before print April 12, 2002, 10.1101/gr.221802. Article published online before print in April 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
GR-2218Rv1
12/5/776    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smith, S. F.
Right arrow Articles by Elgar, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, S. F.
Right arrow Articles by Elgar, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Vol. 12, Issue 5, 776-784, May 2002

LETTER
Analyses of the Extent of Shared Synteny and Conserved Gene Orders between the Genome of Fugu rubripes and Human 20q

Sarah F. Smith,1,5 Philip Snell,1 Frank Gruetzner,2 Anthony J. Bench,3 Thomas Haaf,2 Judith A. Metcalfe,4 Anthony R. Green,3 and Greg Elgar1

1 Fugu Genomics, United Kingdom Human Genome Mapping Project Resource Centre, Wellcome Genome Campus, Hinxton Hall, Hinxton, Cambridgeshire, CB10 1SB, United Kingdom; 2 Max-Planck Institute for Molecular Genetics, 14195 Berlin, Germany; 3 University of Cambridge, Department of Haematology, Cambridge Institute for Medical Research, Cambridge, CB2 2XY, United Kingdom; 4 Department of Biological Sciences, Open University, Milton Keynes, MK7 6AA, United Kingdom.

Cosmid and BAC contig maps have been constructed across two Fugu genomic regions containing the orthologs of human genes mapping to human chromosome 20q. Contig gene contents have been assessed by sample sequencing and comparative database analyses. Contigs are centered around two Fugu topoisomerase1 (top1) genes that were initially identified by sequence similarity to human TOP1 (20q12). Two other genes (SNAI1 and KRML) mapping to human chromosome 20 are also duplicated in Fugu. The two contigs have been mapped to separate Fugu chromosomes. Our data indicate that these linkage groups result from the duplication of an ancestral chromosome segment containing at least 40 genes that now map to the long arm of human chromosome 20. Although there is considerable conservation of synteny, gene orders are not well conserved between Fugu and human, with only very short sections of two to three adjacent genes being maintained in both organisms. Comparative analyses have allowed this duplication event to be dated before the separation of Fugu and zebrafish. Our data (which are best explained by regional duplication, followed by substantial gene loss) support the hypothesis that there have been a large number of gene and regional duplications (and corresponding gene loss) in the fish lineage, possibly resulting from a single whole genome duplication event.

[Reagents, samples, and unpublished information freely provided by D. Barnes and I.D. Hickson.]

5 Corresponding author.

12:776-784 ©2002 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/02 $5.00
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
A. P. Lee, E. G. L. Koh, A. Tay, S. Brenner, and B. Venkatesh
Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters
PNAS, May 2, 2006; 103(18): 6994 - 6999.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
M. Paulsen, T. Khare, C. Burgard, S. Tierling, and J. Walter
Evolution of the Beckwith-Wiedemann syndrome region in vertebrates
Genome Res., January 1, 2005; 15(1): 146 - 153.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
N. J. Cole, T. E. Hall, C. I. Martin, M. A. Chapman, A. Kobiyama, Y. Nihei, S. Watabe, and I. A. Johnston
Temperature and the expression of myogenic regulatory factors (MRFs) and myosin heavy chain isoforms during embryogenesis in the common carp Cyprinus carpio L.
J. Exp. Biol., November 15, 2004; 207(24): 4239 - 4248.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
A. Christoffels, E. G. L. Koh, J.-m. Chia, S. Brenner, S. Aparicio, and B. Venkatesh
Fugu Genome Analysis Provides Evidence for a Whole-Genome Duplication Early During the Evolution of Ray-Finned Fishes
Mol. Biol. Evol., June 1, 2004; 21(6): 1146 - 1151.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. Halling-Brown, C. Sansom, D. S. Moss, G. Elgar, and Y. J. K. Edwards
A Fugu-Human Genome Synteny Viewer: web software for graphical display and annotation reports of synteny between Fugu genomic sequence and human genes
Nucleic Acids Res., May 11, 2004; 32(8): 2618 - 2622.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Vandepoele, W. De Vos, J. S. Taylor, A. Meyer, and Y. Van de Peer
Major events in the genome evolution of vertebrates: Paranome age and size differ considerably between ray-finned fishes and land vertebrates
PNAS, February 10, 2004; 101(6): 1638 - 1643.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
Y. J. K. Edwards, T. J. Carver, T. Vavouri, M. Frith, M. J. Bishop, and G. Elgar
Theatre: a software tool for detailed comparative analysis and visualization of genomic sequence
Nucleic Acids Res., July 1, 2003; 31(13): 3510 - 3517.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Locascio, M. Manzanares, M. J. Blanco, and M. A. Nieto
Modularity and reshuffling of Snail and Slug expression during vertebrate evolution
PNAS, December 24, 2002; 99(26): 16841 - 16846.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
S. Aparicio, J. Chapman, E. Stupka, N. Putnam, J.-m. Chia, P. Dehal, A. Christoffels, S. Rash, S. Hoon, A. Smit, et al.
Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes
Science, August 23, 2002; 297(5585): 1301 - 1310.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genes Dev. Learn. Mem.
Protein Science RNA Genome Res.