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Published online before print February 15, 2002, 10.1101/gr.213002. Article published online before print in February 2002
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Vol. 12, Issue 3, 482-486, March 2002

METHODS
High-Density Cell Microarrays for Parallel Functional Determinations

C. Wilson Xu

Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center and Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA

Whole-genome sequencing projects have generated a wealth of gene sequences from a variety of organisms. A major challenge is to rapidly uncover gene regulatory circuits and their functional manifestations at the cellular level. Here we report the coupled fabrication of nanocraters ranging in size from 100 pL to 1.5 nL on permeable membranes for culturing cells. Using this approach, we developed bacterial and yeast cell microarrays that allowed phenotypic determinations of gene activities and drug targets on a large scale. Cell microarrays will therefore be a particularly useful tool for studying phenotypes of gene activities on a genome-wide scale.

12:482-486 ©2002 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/02 $5.00
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Correction for Xie et al., Insights into TOR function and rapamycin response: Chemical genomic profiling by using a high-density cell array method
PNAS, June 13, 2006; 103(24): 9374 - 9374.
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