Genome Research songbird

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Published online before print November 12, 2002, 10.1101/gr.6049
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
GR-6049v1
12/12/1854    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Betrán, E.
Right arrow Articles by Long, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Betrán, E.
Right arrow Articles by Long, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Vol. 12, Issue 12, 1854-1859, December 2002

LETTER
Retroposed New Genes Out of the X in Drosophila

Esther Betrán,1 Kevin Thornton,2 and Manyuan Long1,2,3

1 Department of Ecology and Evolution; 2 Committee on Genetics, The University of Chicago, Chicago, Illinois 60637, USA

New genes that originated by various molecular mechanisms are an essential component in understanding the evolution of genetic systems. We investigated the pattern of origin of the genes created by retroposition in Drosophila. We surveyed the whole Drosophila melanogaster genome for such new retrogenes and experimentally analyzed their functionality and evolutionary process. These retrogenes, functional as revealed by the analysis of expression, substitution, and population genetics, show a surprisingly asymmetric pattern in their origin. There is a significant excess of retrogenes that originate from the X chromosome and retropose to autosomes; new genes retroposed from autosomes are scarce. Further, we found that most of these X-derived autosomal retrogenes had evolved a testis expression pattern. These observations may be explained by natural selection favoring those new retrogenes that moved to autosomes and avoided the spermatogenesis X inactivation, and suggest the important role of genome position for the origin of new genes.

[The sequence data from this study have been submitted to GenBank under accession nos. AY150701-AY150797. The following individuals kindly provided reagents, samples, or unpublished information as indicated in the paper: M.-L. Wu, F. Lemeunier, and P. Gibert.]

3 Corresponding author.

12:1854-1859 ©2002 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/02 $5.00
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
C. G. Artieri, W. Haerty, B. P. Gupta, and R. S. Singh
Sexual Selection and Maintenance of Sex: Evidence from Comparisons of Rates of Genomic Accumulation of Mutations and Divergence of Sex-Related Genes in Sexual and Hermaphroditic Species of Caenorhabditis
Mol. Biol. Evol., May 1, 2008; 25(5): 972 - 979.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. L. Wayne, M. Telonis-Scott, L. M. Bono, L. Harshman, A. Kopp, S. V. Nuzhdin, and L. M. McIntyre
Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster
PNAS, November 20, 2007; 104(47): 18577 - 18582.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
W. Haerty, S. Jagadeeshan, R. J. Kulathinal, A. Wong, K. Ravi Ram, L. K. Sirot, L. Levesque, C. G. Artieri, M. F. Wolfner, A. Civetta, et al.
Evolution in the Fast Lane: Rapidly Evolving Sex-Related Genes in Drosophila
Genetics, November 1, 2007; 177(3): 1321 - 1335.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
K. R. Thornton
The Neutral Coalescent Process for Recent Gene Duplications and Copy-Number Variants
Genetics, October 1, 2007; 177(2): 987 - 1000.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
M.-S. Shiao, P. Khil, R. D. Camerini-Otero, T. Shiroishi, K. Moriwaki, H.-T. Yu, and M. Long
Origins of New Male Germ-line Functions from X-Derived Autosomal Retrogenes in the Mouse
Mol. Biol. Evol., October 1, 2007; 24(10): 2242 - 2253.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
D. J. Begun, H. A. Lindfors, A. D. Kern, and C. D. Jones
Evidence for de Novo Evolution of Testis-Expressed Genes in the Drosophila yakuba/Drosophila erecta Clade
Genetics, June 1, 2007; 176(2): 1131 - 1137.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
M. E. Feder
Evolvability of physiological and biochemical traits: evolutionary mechanisms including and beyond single-nucleotide mutation
J. Exp. Biol., May 1, 2007; 210(9): 1653 - 1660.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
R. Kalamegham, D. Sturgill, E. Siegfried, and B. Oliver
Drosophila mojoless, a Retroposed GSK-3, Has Functionally Diverged to Acquire an Essential Role in Male Fertility
Mol. Biol. Evol., March 1, 2007; 24(3): 732 - 742.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
E. Betran, Y. Bai, and M. Motiwale
Fast Protein Evolution and Germ Line Expression of a Drosophila Parental Gene and Its Young Retroposed Paralog
Mol. Biol. Evol., November 1, 2006; 23(11): 2191 - 2202.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. P. Masly, C. D. Jones, M. A. F. Noor, J. Locke, and H. A. Orr
Gene transposition as a cause of hybrid sterility in Drosophila.
Science, September 8, 2006; 313(5792): 1448 - 1450.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
I. Dupanloup and H. Kaessmann
Evolutionary simulations to detect functional lineage-specific genes
Bioinformatics, August 1, 2006; 22(15): 1815 - 1822.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
W. Wang, H. Zheng, C. Fan, J. Li, J. Shi, Z. Cai, G. Zhang, D. Liu, J. Zhang, S. Vang, et al.
High Rate of Chimeric Gene Origination by Retroposition in Plant Genomes
PLANT CELL, August 1, 2006; 18(8): 1791 - 1802.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
S. R. Schulze, B. F. McAllister, D. A. R. Sinclair, K. A. Fitzpatrick, M. Marchetti, S. Pimpinelli, and B. M. Honda
Heterochromatic Genes in Drosophila: A Comparative Analysis of Two Genes
Genetics, July 1, 2006; 173(3): 1433 - 1445.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. T. Levine, C. D. Jones, A. D. Kern, H. A. Lindfors, and D. J. Begun
Novel genes derived from noncoding DNA in Drosophila melanogaster are frequently X-linked and exhibit testis-biased expression
PNAS, June 27, 2006; 103(26): 9935 - 9939.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Vinckenbosch, I. Dupanloup, and H. Kaessmann
Evolutionary fate of retroposed gene copies in the human genome
PNAS, February 28, 2006; 103(9): 3220 - 3225.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
M. Ashburner and C. M. Bergman
Drosophila melanogaster: A case study of a model genomic sequence and its consequences
Genome Res., December 1, 2005; 15(12): 1661 - 1667.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. Nozawa, T. Aotsuka, and K. Tamura
A Novel Chimeric Gene, siren, With Retroposed Promoter Sequence in the Drosophila bipectinata Complex
Genetics, December 1, 2005; 171(4): 1719 - 1727.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
D. J. Begun and H. A. Lindfors
Rapid Evolution of Genomic Acp Complement in the melanogaster Subgroup of Drosophila
Mol. Biol. Evol., October 1, 2005; 22(10): 2010 - 2021.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. D. Jones and D. J. Begun
Parallel evolution of chimeric fusion genes
PNAS, August 9, 2005; 102(32): 11373 - 11378.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
A. K. Allan, J. Du, S. A. Davies, and J. A. T. Dow
Genome-wide survey of V-ATPase genes in Drosophila reveals a conserved renal phenotype for lethal alleles
Physiol Genomics, July 14, 2005; 22(2): 128 - 138.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
Y. Zhang, Y. Wu, Y. Liu, and B. Han
Computational Identification of 69 Retroposons in Arabidopsis
Plant Physiology, June 1, 2005; 138(2): 935 - 948.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
C. D. Jones, A. W. Custer, and D. J. Begun
Origin and Evolution of a Chimeric Fusion Gene in Drosophila subobscura, D. madeirensis and D. guanche
Genetics, May 1, 2005; 170(1): 207 - 219.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Maciejowski, J. H. Ahn, P. G. Cipriani, D. J. Killian, A. L. Chaudhary, J. I. Lee, R. Voutev, R. C. Johnsen, D. L. Baillie, K. C. Gunsalus, et al.
Autosomal Genes of Autosomal/X-Linked Duplicated Gene Pairs and Germ-Line Proliferation in Caenorhabditis elegans
Genetics, April 1, 2005; 169(4): 1997 - 2011.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
B. J. Wagstaff and D. J. Begun
Comparative Genomics of Accessory Gland Protein Genes in Drosophila melanogaster and D. pseudoobscura
Mol. Biol. Evol., April 1, 2005; 22(4): 818 - 832.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. M. Good and M. W. Nachman
Rates of Protein Evolution Are Positively Correlated with Developmental Timing of Expression During Mouse Spermatogenesis
Mol. Biol. Evol., April 1, 2005; 22(4): 1044 - 1052.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
K. Thornton and M. Long
Excess of Amino Acid Substitutions Relative to Polymorphism Between X-Linked Duplications in Drosophila melanogaster
Mol. Biol. Evol., February 1, 2005; 22(2): 273 - 284.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
S. Richards, Y. Liu, B. R. Bettencourt, P. Hradecky, S. Letovsky, R. Nielsen, K. Thornton, M. J. Hubisz, R. Chen, R. P. Meisel, et al.
Comparative genome sequencing of Drosophila pseudoobscura: Chromosomal, gene, and cis-element evolution
Genome Res., January 1, 2005; 15(1): 1 - 18.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. L. Wayne, Y.-J. Pan, S. V. Nuzhdin, and L. M. McIntyre
Additivity and trans-acting Effects on Gene Expression in Male Drosophila simulans
Genetics, November 1, 2004; 168(3): 1413 - 1420.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. E. Hood, J. Antonovics, and B. Koskella
Shared Forces of Sex Chromosome Evolution in Haploid-Mating and Diploid-Mating Organisms: Microbotryum violaceum and Other Model Organisms
Genetics, September 1, 2004; 168(1): 141 - 146.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Gonzalez, F. Casals, and A. Ruiz
Duplicative and Conservative Transpositions of Larval serum protein 1 Genes in the Genus Drosophila
Genetics, September 1, 2004; 168(1): 253 - 264.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
H. Sundstrom, M. T. Webster, and H. Ellegren
Reduced Variation on the Chicken Z Chromosome
Genetics, May 1, 2004; 167(1): 377 - 385.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
Z. Zhang and H. Kishino
Genomic Background Predicts the Fate of Duplicated Genes: Evidence From the Yeast Genome
Genetics, April 1, 2004; 166(4): 1995 - 1999.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
Z. Zhang and H. Kishino
Genomic Background Drives the Divergence of Duplicated Amylase Genes at Synonymous Sites in Drosophila
Mol. Biol. Evol., February 1, 2004; 21(2): 222 - 227.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. J. Emerson, H. Kaessmann, E. Betran, and M. Long
Extensive Gene Traffic on the Mammalian X Chromosome
Science, January 23, 2004; 303(5657): 537 - 540.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
G. A. Wray, M. W. Hahn, E. Abouheif, J. P. Balhoff, M. Pizer, M. V. Rockman, and L. A. Romano
The Evolution of Transcriptional Regulation in Eukaryotes
Mol. Biol. Evol., September 1, 2003; 20(9): 1377 - 1419.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
E. Betran and M. Long
Dntf-2r, a Young Drosophila Retroposed Gene With Specific Male Expression Under Positive Darwinian Selection
Genetics, July 1, 2003; 164(3): 977 - 988.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
M. J. Lercher, A. O. Urrutia, and L. D. Hurst
Evidence That the Human X Chromosome Is Enriched for Male-Specific but not Female-Specific Genes
Mol. Biol. Evol., July 1, 2003; 20(7): 1113 - 1116.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. M. Ranz, C. I. Castillo-Davis, C. D. Meiklejohn, and D. L. Hartl
Sex-Dependent Gene Expression and Evolution of the Drosophila Transcriptome
Science, June 13, 2003; 300(5626): 1742 - 1745.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. Parisi, R. Nuttall, D. Naiman, G. Bouffard, J. Malley, J. Andrews, S. Eastman, and B. Oliver
Paucity of Genes on the Drosophila X Chromosome Showing Male-Biased Expression
Science, January 31, 2003; 299(5607): 697 - 700.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genes Dev. Learn. Mem.
Protein Science RNA Genome Res.