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Vol. 11, Issue 8, 1425-1433, August 2001

RESOURCES
Creating the Gene Ontology Resource: Design and Implementation

The Gene Ontology Consortium2

The exponential growth in the volume of accessible biological information has generated a confusion of voices surrounding the annotation of molecular information about genes and their products. The Gene Ontology (GO) project seeks to provide a set of structured vocabularies for specific biological domains that can be used to describe gene products in any organism. This work includes building three extensive ontologies to describe molecular function, biological process, and cellular component, and providing a community database resource that supports the use of these ontologies. The GO Consortium was initiated by scientists associated with three model organism databases: SGD, the Saccharomyces Genome database; FlyBase, the Drosophila genome database; and MGD/GXD, the Mouse Genome Informatics databases. Additional model organism database groups are joining the project. Each of these model organism information systems is annotating genes and gene products using GO vocabulary terms and incorporating these annotations into their respective model organism databases. Each database contributes its annotation files to a shared GO data resource accessible to the public at http://www.geneontology.org/. The GO site can be used by the community both to recover the GO vocabularies and to access the annotated gene product data sets from the model organism databases. The GO Consortium supports the development of the GO database resource and provides tools enabling curators and researchers to query and manipulate the vocabularies. We believe that the shared development of this molecular annotation resource will contribute to the unification of biological information.


2 Alphabetical list of authors in the Gene Ontology Consortium: Michael Ashburner (FlyBase, http://flybase.bio.indiana.edu), Catherine A. Ball (Saccharomyces Genome Database, http://genome-www.stanford.edu), Judith A. Blake (Mouse Genome Database and Gene Expression Database, http://www.informatics.jax.org), Heather Butler (FlyBase, http://flybase.bio.indiana.edu), J. Michael Cherry (Saccharomyces Genome Database, http://genome-www.stanford.edu), John Corradi (Mouse Genome Database and Gene Expression Database, http://www.informatics.jax.org), Kara Dolinski (Saccharomyces Genome Database, http://genome-www.stanford.edu), Janan T. Eppig (Mouse Genome Database and Gene Expression Database, http://www.informatics.jax.org), Midori Harris (Saccharomyces Genome Database, http://genome-www.stanford.edu), David P. Hill (Mouse Genome Database and Gene Expression Database, http://www.informatics.jax.org), Suzanna Lewis (Berkeley Drosophila Genome Project, http://www.fruitfly.org), Brad Marshall (Berkeley Drosophila Genome Project, http://www.fruitfly.org), Chris Mungall (Berkeley Drosophila Genome Project, http://www.fruitfly.org), Leonore Reiser (The Arabidopsis Information Resource, http://www.arabidopsis.org), Sue Rhee (The Arabidopsis Information Resource, http://www.arabidopsis.org), Joel E. Richardson (Mouse Genome Database and Gene Expression Database, http://www.informatics.jax.org), John Richter (Berkeley Drosophila Genome Project, http://www.fruitfly.org), Martin Ringwald (Mouse Genome Database and Gene Expression Database, http://www.informatics.jax.org), Gerald M. Rubin (Berkeley Drosophila Genome Project, http://www.fruitfly.org), Gavin Sherlock (Saccharomyces Genome Database, http://genome-www.stanford.edu), and J. Yoon (The Arabidopsis Information Resource, http://www.arabidopsis.org).


11:1425-1433 ©2001 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/01 $5.00

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