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Vol. 11, Issue 4, 540-546, April 2001

LETTER
Genome-Scale Compositional Comparisons in Eukaryotes

Andrew J. Gentles, and Samuel Karlin1

Mathematics Department, Stanford University, Stanford, California 94305, USA

We examined dinucleotide relative abundances and their biases in recent sequences of eukaryotic genomes and chromosomes, including human chromosomes 21 and 22, Saccharomyces cerevisiae, Arabidopsis thaliana, and Drosophila melanogaster. We found that dinucleotide relative abundances are remarkably constant across human chromosomes and within the DNA of a particular species. The dinucleotide biases differ between species, providing a genome signature that is characteristic of the bulk properties of an organism's DNA. We detail the relations between species genome signatures and suggest possible mechanisms for their origin and maintenance.

1 E-MAIL karlin{at}math.stanford.edu; FAX (650) 725-2040.

11:540-546 ©2001 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/01 $5.00
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