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Published online before print October 15, 2001, 10.1101/gr.194301
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Vol. 11, Issue 11, 1833-1841, November 2001

LETTER
Random Monoallelic Expression of Three Genes Clustered within 60 kb of Mouse t Complex Genomic DNA

Yuri Sano,1,2,6 Tokihiko Shimada,1,6,7 Hiroshi Nakashima,1,2 Rhonda H. Nicholson,3 James F. Eliason,4 Thomas A. Kocarek,5 and Minoru S.H. Ko1,8

1 Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA; 2 Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo 160, Japan; 3 Department of Biological Sciences, 4 Karmanos Cancer Institute, 5 Institute of Chemical Toxicology, Wayne State University, Detroit, Michigan 48201, USA

Mammals achieve gene dosage control by (1) random X-chromosome inactivation in females, (2) parental origin-specific imprinting of selected autosomal genes, and (3) random autosomal inactivation. Genes belonging to the third category of epigenetic phenomenon are just now emerging, with only six identified so far. Here we report three additional genes, Nubp2, Igfals, and Jsap1, that show 50%-methylated CpG sites by Southern blot analyses and primarily monoallelic expression in single-cell allele-specific RT-PCR analysis of bone marrow stromal cells and hepatocytes. Furthermore, we show that, in contrast to X inactivation, alleles can switch between active and inactive states during the formation of daughter cells. These three genes are the first in their category to exist as a tight cluster, in the proximal region of mouse chromosome 17, providing a thus far unique example of a region of autosomal random monoallelic expression.

6 These authors contributed equally to this work.

7 Present address: Department of Dermatology, Kagoshima University Faculty of Medicine, Kagoshima 890-8520, Japan.

8 Corresponding author.

11:1833-1841 ©2001 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/01 $5.00
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