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Vol. 11, Issue 10, 1784-1795, October 2001

RESOURCES
Chromosome-Specific Single-Locus FISH Probes Allow Anchorage of an 1800-Marker Integrated Radiation-Hybrid/Linkage Map of the Domestic Dog Genome to All Chromosomes

Matthew Breen,1,5,6 Sophie Jouquand,2,5 Corinne Renier,2,5 Cathryn S. Mellersh,3,5 Christophe Hitte,2,5 Nigel G. Holmes,1,5 Angélique Chéron,2 Nicola Suter,3,4 Françoise Vignaux,2 Anna E. Bristow,1 Catherine Priat,2 E. McCann,1 Catherine André,2 Sam Boundy,1 Paul Gitsham,1 Rachael Thomas,1,4 Wendy L. Bridge,1 Helen F. Spriggs,1 Ed J. Ryder,1 Alistair Curson,1,4 Jeff Sampson,4 Elaine A. Ostrander,3 Matthew M. Binns,1 and Francis Galibert2,6

1 Genetics Section, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK; 2 UMR 6061 CNRS, Génétique et Développement, Faculté de Médecine, 35043 Rennes Cedex, France; 3 Clinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA; 4 Department of Biochemistry, University of Leicester, Leicester LE1 7RH, UK

We present here the first fully integrated, comprehensive map of the canine genome, incorporating detailed cytogenetic, radiation hybrid (RH), and meiotic information. We have mapped a collection of 266 chromosome-specific cosmid clones, each containing a microsatellite marker, to all 38 canine autosomes by fluorescence in situ hybridization (FISH). A 1500-marker RH map, comprising 1078 microsatellites, 320 dog gene markers, and 102 chromosome-specific markers, has been constructed using the RHDF5000-2 whole-genome radiation hybrid panel. Meiotic linkage analysis was performed, with at least one microsatellite marker from each dog autosome on a panel of reference families, allowing one meiotic linkage group to be anchored to all 38 dog autosomes. We present a karyotype in which each chromosome is identified by one meiotic linkage group and one or more RH groups. This updated integrated map, containing a total of 1800 markers, covers >90% of the dog genome. Positional selection of anchor clones enabled us, for the first time, to orientate nearly all of the integrated groups on each chromosome and to evaluate the extent of individual chromosome coverage in the integrated genome map. Finally, the inclusion of 320 dog genes into this integrated map enhances existing comparative mapping data between human and dog, and the 1000 mapped microsatellite markers constitute an invaluable tool with which to perform genome scanning studies on pedigrees of interest.

5 These authors contributed equally to this work.

6 Corresponding authors.

11:1784-1795 ©2001 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/01 $5.00
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