Genome Research Attend a BioResearch Product Faire

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Published online before print September 20, 2001, 10.1101/gr.192001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
GR-1920Rv1
11/10/1625    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Serluca, F. C.
Right arrow Articles by Fishman, M. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Serluca, F. C.
Right arrow Articles by Fishman, M. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Vol. 11, Issue 10, 1625-1631, October 2001

LETTER
Partitioning of Tissue Expression Accompanies Multiple Duplications of the Na+/K+ ATPase alpha  Subunit Gene

Fabrizio C. Serluca,1 Arend Sidow,2 John D. Mably,1 and Mark C. Fishman1,3

1 Cardiovascular Research Center and Developmental Biology Laboratory, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02119, USA; 2 Departments of Pathology and Genetics, Stanford University, Stanford, California 94305, USA

Vertebrate genomes contain multiple copies of related genes that arose through gene duplication. In the past it has been proposed that these duplicated genes were retained because of acquisition of novel beneficial functions. A more recent model, the duplication-degeneration-complementation hypothesis (DDC), posits that the functions of a single gene may become separately allocated among the duplicated genes, rendering both duplicates essential. Thus far, empirical evidence for this model has been limited to the engrailed and sox family of developmental regulators, and it has been unclear whether it may also apply to ubiquitously expressed genes with essential functions for cell survival. Here we describe the cloning of three zebrafish alpha  subunits of the Na(+),K(+)-ATPase and a comprehensive evolutionary analysis of this gene family. The predicted amino acid sequences are extremely well conserved among vertebrates. The evolutionary relationships and the map positions of these genes and of other alpha -like sequences indicate that both tandem and ploidy duplications contributed to the expansion of this gene family in the teleost lineage. The duplications are accompanied by acquisition of clear functional specialization, consistent with the DDC model of genome evolution.

[The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AY028628, AY028629, and AY028630]

3 Corresponding author.

11:1625-1631 ©2001 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/01 $5.00
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
X. Shu, J. Huang, Y. Dong, J. Choi, A. Langenbacher, and J.-N. Chen
Na,K-ATPase {alpha}2 and Ncx4a regulate zebrafish left-right patterning
Development, May 15, 2007; 134(10): 1921 - 1930.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
V. S. Silva, A. I. Duarte, A. C. Rego, C. R. Oliveira, and P. P. Goncalves
Effect of Chronic Exposure to Aluminium on Isoform Expression and Activity of Rat (Na+/K+)ATPase
Toxicol. Sci., December 1, 2005; 88(2): 485 - 494.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Yuan and E. M. Joseph
The small heart Mutation Reveals Novel Roles of Na+/K+-ATPase in Maintaining Ventricular Cardiomyocyte Morphology and Viability in Zebrafish
Circ. Res., September 17, 2004; 95(6): 595 - 603.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
X. Shu, K. Cheng, N. Patel, F. Chen, E. Joseph, H.-J. Tsai, and J.-N. Chen
Na,K-ATPase is essential for embryonic heart development in the zebrafish
Development, December 22, 2003; 130(25): 6165 - 6173.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. Dorus, S. L. Gilbert, M. L. Forster, R. J. Barndt, and B. T. Lahn
The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence
Hum. Mol. Genet., July 15, 2003; 12(14): 1643 - 1650.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
C. Winkler, M. Schafer, J. Duschl, M. Schartl, and J.-N. Volff
Functional Divergence of Two Zebrafish Midkine Growth Factors Following Fish-Specific Gene Duplication
Genome Res., June 1, 2003; 13(6): 1067 - 1081.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Altschmied, J. Delfgaauw, B. Wilde, J. Duschl, L. Bouneau, J.-N. Volff, and M. Schartl
Subfunctionalization of Duplicate mitf Genes Associated With Differential Degeneration of Alternative Exons in Fish
Genetics, May 1, 2002; 161(1): 259 - 267.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
C.-K. J. Shen
Sharing Duties in the Family
Genome Res., October 1, 2001; 11(10): 1615 - 1615.
[Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genes Dev. Learn. Mem.
Protein Science RNA Genome Res.