Genome Research cityscape

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Research Data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barbazuk, W. B.
Right arrow Articles by Johnson, S. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barbazuk, W. B.
Right arrow Articles by Johnson, S. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Vol. 10, Issue 9, 1351-1358, September 2000

LETTER
The Syntenic Relationship of the Zebrafish and Human Genomes

W. Bradley Barbazuk,1,3 Ian Korf,1 Candy Kadavi,1 Joshua Heyen,1 Stephanie Tate,1 Edmund Wun,2 Joseph A. Bedell,1 John D. McPherson,1 and Stephen L. Johnson2,4

1 Washington University School of Medicine Genome Sequencing Center, St. Louis, Missouri 63108 USA; 2 Department of Genetics, Washington University Medical School, St. Louis, Missouri 63130 USA

The zebrafish is an important vertebrate model for the mutational analysis of genes effecting developmental processes. Understanding the relationship between zebrafish genes and mutations with those of humans will require understanding the syntenic correspondence between the zebrafish and human genomes. High throughput gene and EST mapping projects in zebrafish are now facilitating this goal. Map positions for 523 zebrafish genes and ESTs with predicted human orthologs reveal extensive contiguous blocks of synteny between the zebrafish and human genomes. Eighty percent of genes and ESTs analyzed belong to conserved synteny groups (two or more genes linked in both zebrafish and human) and 56% of all genes analyzed fall in 118 homology segments (uninterrupted segments containing two or more contiguous genes or ESTs with conserved map order between the zebrafish and human genomes). This work now provides a syntenic relationship to the human genome for the majority of the zebrafish genome.

3 Present address: Monsanto World Headquarters, St. Louis, Missouri 63167 USA.

4 Corresponding author.

10:1351-1358 ©2000 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/00 $5.00
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
M. Sekino and M. Hara
Linkage Maps for the Pacific Abalone (Genus Haliotis) Based on Microsatellite DNA Markers
Genetics, February 1, 2007; 175(2): 945 - 958.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
P. J. Schlueter, T. Royer, M. H. Farah, B. Laser, S. J. Chan, D. F. Steiner, and C. Duan
Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors
FASEB J, June 1, 2006; 20(8): 1230 - 1232.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
H. Roest Crollius and J. Weissenbach
Fish genomics and biology
Genome Res., December 1, 2005; 15(12): 1675 - 1682.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
B. E. Shmukler, C. E. Kurschat, G. E. Ackermann, L. Jiang, Y. Zhou, B. Barut, A. K. Stuart-Tilley, J. Zhao, L. I. Zon, I. A. Drummond, et al.
Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization
Am J Physiol Renal Physiol, October 1, 2005; 289(4): F835 - F849.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
I. G. Woods, C. Wilson, B. Friedlander, P. Chang, D. K. Reyes, R. Nix, P. D. Kelly, F. Chu, J. H. Postlethwait, and W. S. Talbot
The zebrafish gene map defines ancestral vertebrate chromosomes
Genome Res., September 1, 2005; 15(9): 1307 - 1314.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
H. Diekmann, M. Klinger, T. Oertle, D. Heinz, H.-M. Pogoda, M. E. Schwab, and C. A. O. Stuermer
Analysis of the Reticulon Gene Family Demonstrates the Absence of the Neurite Growth Inhibitor Nogo-A in Fish
Mol. Biol. Evol., August 1, 2005; 22(8): 1635 - 1648.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y.-L. Yan, J. Willoughby, D. Liu, J. G. Crump, C. Wilson, C. T. Miller, A. Singer, C. Kimmel, M. Westerfield, and J. H. Postlethwait
A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development
Development, March 1, 2005; 132(5): 1069 - 1083.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
H. Tostivint, L. Joly, I. Lihrmann, M. Ekker, and H. Vaudry
Chromosomal localization of three somatostatin genes in zebrafish. Evidence that the [Pro2]-somatostatin-14 isoform and cortistatin are encoded by orthologous genes
J. Mol. Endocrinol., December 1, 2004; 33(3): R1 - R8.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H.-D. Song, X.-J. Sun, M. Deng, G.-W. Zhang, Y. Zhou, X.-Y. Wu, Y. Sheng, Y. Chen, Z. Ruan, C.-L. Jiang, et al.
Hematopoietic gene expression profile in zebrafish kidney marrow
PNAS, November 16, 2004; 101(46): 16240 - 16245.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
A. Christoffels, E. G. L. Koh, J.-m. Chia, S. Brenner, S. Aparicio, and B. Venkatesh
Fugu Genome Analysis Provides Evidence for a Whole-Genome Duplication Early During the Evolution of Ray-Finned Fishes
Mol. Biol. Evol., June 1, 2004; 21(6): 1146 - 1151.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
K. Naruse, M. Tanaka, K. Mita, A. Shima, J. Postlethwait, and H. Mitani
A Medaka Gene Map: The Trace of Ancestral Vertebrate Proto-Chromosomes Revealed by Comparative Gene Mapping
Genome Res., May 1, 2004; 14(5): 820 - 828.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Paukert, S. Sidi, C. Russell, M. Siba, S. W. Wilson, T. Nicolson, and S. Grunder
A Family of Acid-sensing Ion Channels from the Zebrafish: WIDESPREAD EXPRESSION IN THE CENTRAL NERVOUS SYSTEM SUGGESTS A CONSERVED ROLE IN NEURONAL COMMUNICATION
J. Biol. Chem., April 30, 2004; 279(18): 18783 - 18791.
[Abstract] [Full Text] [PDF]

Home page
 J HeredHome page
D. W. Severson, B. deBruyn, D. D. Lovin, S. E. Brown, D. L. Knudson, and I. Morlais
Comparative Genome Analysis of the Yellow Fever Mosquito Aedes aegypti with Drosophila melanogaster and the Malaria Vector Mosquito Anopheles gambiae
J. Hered., March 1, 2004; 95(2): 103 - 113.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
J. S. Taylor, I. Braasch, T. Frickey, A. Meyer, and Y. Van de Peer
Genome Duplication, a Trait Shared by 22,000 Species of Ray-Finned Fish
Genome Res., March 1, 2003; 13(3): 382 - 390.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. F. Rawls, M. R. Frieda, A. R. McAdow, J. P. Gross, C. M. Clayton, C. K. Heyen, and S. L. Johnson
Coupled Mutagenesis Screens and Genetic Mapping in Zebrafish
Genetics, March 1, 2003; 163(3): 997 - 1009.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
J. M. Spitsbergen and M. L. Kent
The State of the Art of the Zebrafish Model for Toxicology and Toxicologic Pathology Research--Advantages and Current Limitations
Toxicol Pathol, January 1, 2003; 31(1_suppl): 62 - 87.
[Abstract] [PDF]

Home page
 Genome Res.Home page
H. L. Stickney, J. Schmutz, I. G. Woods, C. C. Holtzer, M. C. Dickson, P. D. Kelly, R. M. Myers, and W. S. Talbot
Rapid Mapping of Zebrafish Mutations With SNPs and Oligonucleotide Microarrays
Genome Res., December 1, 2002; 12(12): 1929 - 1934.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
F. Grutzner, H. R. Crollius, G. Lutjens, O. Jaillon, J. Weissenbach, H.-H. Ropers, and T. Haaf
Four-Hundred Million Years of Conserved Synteny of Human Xp and Xq Genes on Three Tetraodon Chromosomes
Genome Res., September 1, 2002; 12(9): 1316 - 1322.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
E. A. Andreasen, M. E. Hahn, W. Heideman, R. E. Peterson, and R. L. Tanguay
The Zebrafish (Danio rerio) Aryl Hydrocarbon Receptor Type 1 Is a Novel Vertebrate Receptor
Mol. Pharmacol., August 1, 2002; 62(2): 234 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. M. Prescott and H. J. Yost
The COXes of Danio: From mechanistic model to experimental therapeutics
PNAS, July 9, 2002; 99(14): 9084 - 9086.
[Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. N. Neely, J. D. Pfeifer, and M. Caparon
Streptococcus-Zebrafish Model of Bacterial Pathogenesis
Infect. Immun., July 1, 2002; 70(7): 3904 - 3914.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. X. Liu, Y. Zhou, J. P. Kanki, M. Deng, J. Rhodes, H. W. Yang, X. M. Sheng, L. I. Zon, and A. T. Look
Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies
PNAS, April 30, 2002; 99(9): 6136 - 6141.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. I. Karchner, D. G. Franks, W. H. Powell, and M. E. Hahn
Regulatory Interactions among Three Members of the Vertebrate Aryl Hydrocarbon Receptor Family: AHR Repressor, AHR1, and AHR2
J. Biol. Chem., February 22, 2002; 277(9): 6949 - 6959.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Singer, H. Perlman, Y. Yan, C. Walker, G. Corley-Smith, B. Brandhorst, and J. Postlethwait
Sex-Specific Recombination Rates in Zebrafish (Danio rerio)
Genetics, February 1, 2002; 160(2): 649 - 657.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. Okubo, S. Nagata, R. Ko, H. Kataoka, Y. Yoshiura, H. Mitani, M. Kondo, K. Naruse, A. Shima, and K. Aida
Identification and Characterization of Two Distinct GnRH Receptor Subtypes in a Teleost, the Medaka Oryzias latipes
Endocrinology, November 1, 2001; 142(11): 4729 - 4739.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
R. P. M. A. Crooijmans, R. J. M. Dijkhof, T. Veenendaal, J. J. van der Poel, R. D. Nicholls, H. Bovenhuis, and M. A. M. Groenen
The Gene Orders on Human Chromosome 15 and Chicken Chromosome 10 Reveal Multiple Inter- and Intrachromosomal Rearrangements
Mol. Biol. Evol., November 1, 2001; 18(11): 2102 - 2109.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Kollmar, S. K. Nakamura, J. A. Kappler, and A. J. Hudspeth
Expression and phylogeny of claudins in vertebrate primordia
PNAS, August 17, 2001; (2001) 171325898.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. A. Yoder, M. G. Mueller, S. Wei, B. C. Corliss, D. M. Prather, T. Willis, R. T. Litman, J. Y. Djeu, and G. W. Litman
Immune-type receptor genes in zebrafish share genetic and functional properties with genes encoded by the mammalian leukocyte receptor cluster
PNAS, May 24, 2001; (2001) 121101598.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
M. Robinson-Rechavi, O. Marchand, H. Escriva, P.-L. Bardet, D. Zelus, S. Hughes, and V. Laudet
Euteleost Fish Genomes are Characterized by Expansion of Gene Families
Genome Res., May 1, 2001; 11(5): 781 - 788.
[Abstract] [Full Text]

Home page
 ScienceHome page
J. C. Venter, M. D. Adams, E. W. Myers, P. W. Li, R. J. Mural, G. G. Sutton, H. O. Smith, M. Yandell, C. A. Evans, R. A. Holt, et al.
The Sequence of the Human Genome
Science, February 16, 2001; 291(5507): 1304 - 1351.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. A. Yoder, M. G. Mueller, S. Wei, B. C. Corliss, D. M. Prather, T. Willis, R. T. Litman, J. Y. Djeu, and G. W. Litman
Immune-type receptor genes in zebrafish share genetic and functional properties with genes encoded by the mammalian leukocyte receptor cluster
PNAS, June 5, 2001; 98(12): 6771 - 6776.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Kollmar, S. K. Nakamura, J. A. Kappler, and A. J. Hudspeth
Expression and phylogeny of claudins in vertebrate primordia
PNAS, August 28, 2001; 98(18): 10196 - 10201.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
M. D. Clark, S. Hennig, R. Herwig, S. W. Clifton, M. A. Marra, H. Lehrach, S. L. Johnson, and t. W.-G. E. Group
An Oligonucleotide Fingerprint Normalized and Expressed Sequence Tag Characterized Zebrafish cDNA Library
Genome Res., September 1, 2001; 11(9): 1594 - 1602.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
N. Hukriede, D. Fisher, J. Epstein, L. Joly, P. Tellis, Y. Zhou, B. Barbazuk, K. Cox, L. Fenton-Noriega, C. Hersey, et al.
The LN54 Radiation Hybrid Map of Zebrafish Expressed Sequences
Genome Res., December 1, 2001; 11(12): 2127 - 2132.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
S. F. Smith, P. Snell, F. Gruetzner, A. J. Bench, T. Haaf, J. A. Metcalfe, A. R. Green, and G. Elgar
Analyses of the Extent of Shared Synteny and Conserved Gene Orders between the Genome of Fugu rubripes and Human 20q
Genome Res., May 1, 2002; 12(5): 776 - 784.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
M.-C. Chen, Y. Zhou, and H. W. Detrich III
Zebrafish mitotic kinesin-like protein 1 (Mklp1) functions in embryonic cytokinesis
Physiol Genomics, February 11, 2002; 8(1): 51 - 66.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genes Dev. Learn. Mem.
Protein Science RNA Genome Res.