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Vol. 10, Issue 9, 1304-1306, September 2000

REPORT
Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons

Inna Dubchak,1 Michael Brudno,1 Gabriela G. Loots,2 Lior Pachter,3 Chris Mayor,1 Edward M. Rubin,2 and Kelly A. Frazer2,4,5

1 Center for Bioinformatics and Computational Genomics, 2 Genome Sciences Department, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA; 3 Department of Mathematics, University of California at Berkeley, Berkeley, California 94720, USA

Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human-mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.

[The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF276990.]


4 Present address: Affymetrix, Santa Clara, California 95051 USA.

5 Corresponding author.


10:1304-1306 ©2000 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/00 $5.00

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