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Vol. 10, Issue 4, 547-548, April 2000

METHODS
Using GeneWise in the Drosophila Annotation Experiment

Ewan Birney,1 and Richard Durbin

Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK

The GeneWise method for combining gene prediction and homology searches was applied to the 2.9-Mb region from Drosophila melanogaster. The results from the Genome Annotation Assessment Project (GASP) showed that GeneWise provided reasonably accurate gene predictions. Further investigation indicates that many of the incorrect gene predictions from GeneWise were due to transposons with valid protein-coding genes and the remaining cases are pseudogenes or possible annotation oversights.

1 Corresponding author.

10:547-548 ©2000 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/00 $5.00
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