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Vol. 10, Issue 4, 539-542, April 2000

METHODS
Promoter Prediction on a Genomic Scale---The Adh Experience

Uwe Ohler

Lehrstuhl für Mustererkennung, University of Erlangen-Nuremberg, D-91058 Erlangen, Germany and Berkeley Drosophila Genome Project, University of California at Berkeley, Berkeley, California 94720 USA

We describe our statistical system for promoter recognition in genomic DNA with which we took part in the Genome Annotation Assessment Project (GASP1). We applied two versions of the system: the first uses a region-based approach toward transcription start site identification, namely, interpolated Markov chains; the second was a hybrid approach combining regions and signals within a stochastic segment model. We compare the results of both versions with each other and examine how well the application on a genomic scale compares with the results we previously obtained on smaller data sets.

10:539-542 ©2000 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/00 $5.00
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