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Vol. 10, Issue 11, 1672-1678, November 2000

REPORTS
Is "Junk" DNA Mostly Intron DNA?

Gane Ka-Shu Wong,1,3 Douglas A. Passey,1 Ying-zong Huang,1 Zhiyong Yang,1 and Jun Yu1,2

1 Human Genome Center, Department of Medicine, University of Washington, Seattle, Washington 98195, USA; 2 Human Genome Center, Institute of Genetics, Chinese Academy of Sciences, Beijing, China

Among higher eukaryotes, very little of the genome codes for protein. What is in the rest of the genome, or the "junk" DNA, that, in Homo sapiens, is estimated to be almost 97% of the genome? Is it possible that much of this "junk" is intron DNA? This is not a question that can be answered just by looking at the published data, even from the finished genomes. One cannot assume that there are no genes in a sequenced region, just because no genes were annotated. We introduce another approach to this problem, based on an analysis of the cDNA-to-genomic alignments, in all of the complete or nearly-complete genomes from the multicellular organisms. Our conclusion is that, in animals but not in plants, most of the "junk" is intron DNA.

3 Corresponding author.

10:1672-1678 ©2000 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/00 $5.00
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