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Vol. 10, Issue 10, 1453-1462, October 2000

REPORTS
Organization of Mouse Iroquois Homeobox Genes in Two Clusters Suggests a Conserved Regulation and Function in Vertebrate Development

Thomas Peters,1,2 Renate Dildrop,1,2 Katrin Ausmeier,1,3 and Ulrich Rüther1,4

1 Entwicklungs- und Molekularbiologie der Tiere, Heinrich-Heine-Universität, 40225 Düsseldorf, Germany

Iroquois proteins comprise a conserved family of homeodomain-containing transcription factors involved in patterning and regionalization of embryonic tissues in both vertebrates and invertebrates. Earlier studies identified four murine Iroquois (Irx) genes. Here we report the isolation of two additional members of the murine gene family, Irx5 and Irx6. Phylogenetic analysis of the Irx gene family revealed distinct clades for fly and vertebrate genes, and vertebrate members themselves were classified into three pairs of cognate genes. Mapping of the murine Irx genes identified two gene clusters located on mouse chromosomes 8 and 13, respectively. Each gene cluster is represented by three Irx genes whose relative positions within both clusters are strictly conserved. Combined results from phylogenetic, linkage, and physical mapping studies provide evidence for the evolution of two Irx gene clusters by duplication of a larger chromosomal region and dispersion to two chromosomal locations. The maintenance of two cognate Irx gene clusters during vertebrate evolution suggests that their genomic organization is important for the regulation, expression, and function of Irx genes during embryonic development.

[The sequence data in this paper have been submitted to the EMBL Nucleotide Sequence Database under accession nos. AJ271053, AJ271054, AJ271055.]

2 These authors contributed equally to this paper.

3 Present address: Institut für Molekularbiologie, MHH, 30625 Hannover, Germany.

4 Corresponding author.

10:1453-1462 ©2000 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/00 $5.00
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