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Vol. 10, Issue 1, 137-147, January 2000

RESOURCE
A Consensus Linkage Map of the Chicken Genome

Martien A.M. Groenen,1,15 Hans H. Cheng,2 Nat Bumstead,3 Bernard F. Benkel,4 W. Elwood Briles,5 Terry Burke,6 Dave W. Burt,7 Lyman B. Crittenden,8 Jerry Dodgson,8 Jossi Hillel,9 Sue Lamont,10 Abel Ponce de Leon,11 Morris Soller,12 Hideaki Takahashi,13 and Alain Vignal14

1 Animal Breeding and Genetics Group, Wageningen Institute of Animal Sciences, Wageningen University, 6709 PG Wageningen, The Netherlands; 2 United States Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, Michigan 48823 USA; 3 Molecular Biology, Institute for Animal Health, Compton Laboratory, Compton, Berkshire RG20 7NN, UK; 4 Agriculture and Agro-Food Canada, Center for Food and Animal Research, Ottawa KIA 0C6, Canada; 5 Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115 USA; 6 Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK; 7 Department of Molecular Biology, Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS, UK; 8 Michigan State University, Department of Microbiology, East Lansing, Michigan 48823 USA; 9 Department of Genetics, The Hebrew University of Jerusalem, Rehovot 76100, Israel; 10 Department of Animal Science, Iowa State University, Ames, Iowa 50011-3150 USA ; 11 Department of Animal Science, University of Minnesota, St. Paul, Minnesota 55108 USA; 12 Department of Genetics, Silberman Life Science Institute, The Hebrew University of Jerusalem, Jerusalem, 91904 Israel; 13 Department of Genetic Resources 1, National Institute of Agrobiological Resources, Kannondai, Tsukuba 305-8602, Japan; 14 Institute National de la Recherche Agronomique, Genetique Animale, Laboratoire de Genetique Cellulaire, 31326 Castanet-Tolosan, France

A consensus linkage map has been developed in the chicken that combines all of the genotyping data from the three available chicken mapping populations. Genotyping data were contributed by the laboratories that have been using the East Lansing and Compton reference populations and from the Animal Breeding and Genetics Group of the Wageningen University using the Wageningen/Euribrid population. The resulting linkage map of the chicken genome contains 1889 loci. A framework map is presented that contains 480 loci ordered on 50 linkage groups. Framework loci are defined as loci whose order relative to one another is supported by odds greater then 3. The possible positions of the remaining 1409 loci are indicated relative to these framework loci. The total map spans 3800 cM, which is considerably larger than previous estimates for the chicken genome. Furthermore, although the physical size of the chicken genome is threefold smaller then that of mammals, its genetic map is comparable in size to that of most mammals. The map contains 350 markers within expressed sequences, 235 of which represent identified genes or sequences that have significant sequence identity to known genes. This improves the contribution of the chicken linkage map to comparative gene mapping considerably and clearly shows the conservation of large syntenic regions between the human and chicken genomes. The compact physical size of the chicken genome, combined with the large size of its genetic map and the observed degree of conserved synteny, makes the chicken a valuable model organism in the genomics as well as the postgenomics era. The linkage maps, the two-point lod scores, and additional information about the loci are available at web sites in Wageningen (http://www.zod.wau.nl/vf/research/chicken/frame_chicken.html) and East Lansing (http://poultry.mph.msu.edu/).


15 Corresponding author.


10:137-147 ©2000 by Cold Spring Harbor Laboratory Press  ISSN 1088-9051/00 $5.00

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